Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Biomed Res Int. 2017;2017:4281629. doi: 10.1155/2017/4281629. Epub 2017 Sep 17.
To investigate the clinical relevance of plaque's morphological characteristics and distribution pattern using 3.0 T high-resolution magnetic resonance imaging (HRMRI) in patients with moderate or severe basilar artery (BA) atherosclerosis stenosis.
Fifty-seven patients (33 symptomatic patients and 24 asymptomatic patients) were recruited for 3.0 T HRMRI scan; all of them had >50% stenosis on the BA. The intraplaque hemorrhage (IPH), contrast-enhancement pattern, and distribution of BA plaques were compared between the symptomatic and asymptomatic groups. Factors potentially associated with posterior ischemic stroke were calculated by multivariate analyses.
Enhancement of BA plaque was more frequently observed in symptomatic than in asymptomatic patients (27/33, 81.8% versus 11/24, 45.8%; < 0.01). In multivariate regression analysis, plaque enhancement (OR = 7.193; 95% CI: 1.880-27.517; = 0.004) and smoking (OR = 4.402; 95% CI: 2.218-15.909; = 0.024) were found to be independent risk factors of posterior ischemic events in patients with BA stenosis >50%. Plaques were mainly distributed at the ventral site (39.3%) or involved more than two arcs (21.2%) in the symptomatic group but were mainly distributed at left (33.3%) and right (25.0%) sites in the asymptomatic group.
使用 3.0T 高分辨率磁共振成像（HRMRI）研究斑块的形态特征和分布模式与中重度基底动脉（BA）粥样硬化狭窄患者的临床相关性。
共招募 57 例患者（33 例有症状患者和 24 例无症状患者）进行 3.0T HRMRI 扫描；所有患者的 BA 狭窄率均>50%。比较有症状和无症状组患者的斑块内出血（IPH）、对比增强模式和 BA 斑块的分布情况。通过多变量分析计算与后部缺血性卒中相关的潜在因素。
与无症状患者（24/24，45.8%）相比，有症状患者的 BA 斑块增强更为常见（27/33，81.8%）（<0.01）。多变量回归分析显示，斑块增强（OR=7.193；95%CI：1.880-27.517；=0.004）和吸烟（OR=4.402；95%CI：2.218-15.909；=0.024）是 BA 狭窄>50%患者发生后部缺血事件的独立危险因素。有症状组的斑块主要分布在腹侧部位（39.3%）或累及两个以上弧形（21.2%），而无症状组的斑块主要分布在左侧（33.3%）和右侧（25.0%）。
