Cagino Kristen, Levitan Daniel, Schatz-Siemers Nina, Zarnegar Rasa, Chapman-Davis Eloise, Holcomb Kevin, Frey Melissa
Department of Gynecologic Oncology, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10021, USA.
Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10021, USA.
Ecancermedicalscience. 2020 Feb 4;14:1009. doi: 10.3332/ecancer.2020.1009. eCollection 2020.
Malignant transformation of mature cystic teratomas (MCTs) is a rare phenomenon. The most common histology of a malignant transformation is squamous cell carcinoma, and there are limited reports of multiple malignancies arising in a single MCT. Further data are necessary to guide management of these atypical cases.
We present the case of a 48-year-old with MCT containing a malignant papillary thyroid carcinoma (PTC) arising in the context of struma ovarii and a carcinoid tumour.
Malignant transformations of MCTs are exceedingly rare with no guidelines on management. We use this case to demonstrate an approach for the workup and management of malignantly transformed MCTs.
成熟性囊性畸胎瘤（MCT）的恶性转化是一种罕见现象。恶性转化最常见的组织学类型是鳞状细胞癌，关于单个MCT发生多种恶性肿瘤的报道有限。需要更多数据来指导这些非典型病例的管理。
我们报告一例48岁患者，其MCT合并卵巢甲状腺肿背景下发生的恶性乳头状甲状腺癌（PTC）和类癌肿瘤。
MCT的恶性转化极为罕见，且尚无管理指南。我们通过该病例展示了恶性转化MCT的检查和管理方法。
