利奈唑胺诱发的精神病和幻觉：病例报告及文献综述
Linezolid induced psychosis and hallucination: Case report and literature review.
作者信息
Maqsood Hamza, Sajjad Salman, Aslam Saba, Younus Shifa, Naveed Sadiq
机构信息
Nishtar Medical University and Hospital, Multan, Pakistan.
Child and Adolescent Inpatient Units, Institute of Living, Hartford, CT, USA.
出版信息
Ann Med Surg (Lond). 2022 Oct 13;83:104654. doi: 10.1016/j.amsu.2022.104654. eCollection 2022 Nov.
INTRODUCTION
Various classes of antibiotics have been linked to causing a wide range of neuropsychiatric symptoms. These manifestations range from psychosis and delirium to encephalitis and intracranial hypertension. The prevalence of psychosis adverse drug reactions (ADRs) for individual antibiotics ranges from 0.3 to 3.8%. We report a rare case of linezolid-induced psychosis and hallucination.
CASE PRESENTATION
We report a 52-year-old Asian gentleman who presented with an altered level of consciousness and hallucinations. He was treated for third-degree burns of 31% of the body for two months. Based on clinical and laboratory investigations, linezolid-induced psychosis and hallucination were diagnosed. His Naranjo probability score was +8. The drug was stopped, and the patient recovered successfully.
CONCLUSION
On rare occasions, toxic blood levels of linezolid can lead to neuropsychiatric manifestations. Both linezolid-induced psychosis and hallucinations are manageable by suspension of the drug. Therefore, physicians should monitor the blood levels of this antibiotic to keep their patients safe from such serious adverse effects.
引言
各类抗生素已被证实与引发多种神经精神症状有关。这些表现范围从精神病和谵妄到脑炎和颅内高压。个别抗生素引发精神病不良反应（ADR）的发生率在0.3%至3.8%之间。我们报告一例罕见的利奈唑胺所致精神病和幻觉病例。
病例介绍
我们报告一名52岁的亚洲男性，出现意识水平改变和幻觉。他因31%体表面积的三度烧伤接受了两个月的治疗。基于临床和实验室检查，诊断为利奈唑胺所致精神病和幻觉。他的纳伦霍概率评分为+8。停用该药物后，患者成功康复。
结论
在极少数情况下，利奈唑胺的血液中毒水平可导致神经精神表现。利奈唑胺所致精神病和幻觉均可通过停药来控制。因此，医生应监测这种抗生素的血液水平，以确保患者免受此类严重不良反应的影响。
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