Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Front Immunol. 2022 Oct 27;13:1028893. doi: 10.3389/fimmu.2022.1028893. eCollection 2022.
Increasing evidence suggested that gaseous pollutants were associated with the development of autoimmune diseases, while there were few studies on the association between gaseous pollutants and Sjögren's syndrome (SS). This study sought to assess the relationship between exposure to several gaseous pollutants and the hospitalizations for SS.
The data regarding SS hospitalizations, gaseous pollutants, and meteorological factors in Hefei from 2016 to 2021 were collected. A distributed lag non-linear model combined with a generalized linear model were adopted to analyze the association between gaseous pollutants and SS hospitalizations, and stratified analyses were also conducted.
We detected significant associations between gaseous pollutants (NO, SO, O, CO) and SS hospitalizations. Exposure to NO was linked with the elevated risk of hospitalizations for SS (=1.026, lag1 day). A positive correlation between CO exposure and hospitalizations for SS was found (=1.144, lag2 day). In contrast, exposure to SO, O was respectively related to the decreased risk of hospitalizations for SS (SO: =0.897, lag14 day; O: =0.992, lag9 day). Stratified analyses found that female patients were more vulnerable to these gaseous pollutants. SS patients ≥ 65 years were more susceptible to NO, CO exposure, and younger patients were more vulnerable to O exposure. In addition, exposure to O, CO in cold season were more likely to affect hospitalizations for SS.
Our results demonstrated a significant association between exposure to NO, CO and elevated risk of hospitalizations for SS, and SO, O exposure might be linked to reduced risk of SS hospitalizations.
越来越多的证据表明气态污染物与自身免疫性疾病的发展有关，而关于气态污染物与干燥综合征（SS）之间的关系的研究较少。本研究旨在评估几种气态污染物暴露与 SS 住院治疗之间的关系。
收集了 2016 年至 2021 年合肥地区 SS 住院、气态污染物和气象因素的数据。采用分布式滞后非线性模型结合广义线性模型分析气态污染物与 SS 住院之间的关系，并进行了分层分析。
我们检测到气态污染物（NO、SO、O、CO）与 SS 住院之间存在显著关联。暴露于 NO 与 SS 住院的风险升高有关（=1.026，滞后 1 天）。CO 暴露与 SS 住院之间存在正相关（=1.144，滞后 2 天）。相比之下，暴露于 SO 和 O 与 SS 住院的风险降低有关（SO：=0.897，滞后 14 天；O：=0.992，滞后 9 天）。分层分析发现女性患者更容易受到这些气态污染物的影响。≥65 岁的 SS 患者更容易受到 NO 和 CO 暴露的影响，而年轻患者更容易受到 O 暴露的影响。此外，冷季暴露于 O 和 CO 更有可能影响 SS 的住院治疗。
我们的研究结果表明，暴露于 NO 和 CO 与 SS 住院治疗的风险升高显著相关，而暴露于 SO 和 O 可能与 SS 住院治疗的风险降低有关。
