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中国湿润亚热带地区环境空气污染与痛风住院之间的关系。

The Relationship Between Ambient Air Pollution and Hospitalizations for Gout in a Humid Subtropical Region of China.

作者信息

He Yi-Sheng, Wang Gui-Hong, Wu Qian, Wu Zheng-Dong, Chen Yue, Tao Jin-Hui, Fang Xin-Yu, Xu Zhiwei, Pan Hai-Feng

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People's Republic of China.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, People's Republic of China.

出版信息

J Inflamm Res. 2021 Nov 4;14:5827-5835. doi: 10.2147/JIR.S329706. eCollection 2021.

DOI:10.2147/JIR.S329706
PMID:34764674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8575452/
Abstract

OBJECTIVE

Gout is a chronic disease caused by the deposition of sodium urate (MSU) crystals. Available data on the association between environmental hazards and gout are scarce. The present study was present to investigate the relationship between short-term exposure to air pollution and hospitalizations for acute gout from 2016 to 2020 in Anqing City, China.

METHODS

Daily records of hospital admissions for acute gout in Anqing from 1 January 2016 to 31 December 2020 were retrieved from the tertiary first-class hospitals in Anqing. Air pollutants and meteorological data were obtained from the China Environmental Monitoring Station and China Meteorological Data Service Center respectively. We used a time-series analysis to explore the association between air pollution (NO, O, and CO) and hospitalizations for acute gout, and conducted stratified analyses by gender, age and season.

RESULTS

We observed an association between NO and hospitalizations for gout (lag 0, relative risk (RR):1.022, 95% confidence interval (CI):1.004-1.041). For every 1 mg/m increase in CO concentration, hospitalizations for gout increased by 3.9% (lag 11 days, RR=1.039, 95% CI: 1.004-1.076). Intriguingly, there was a negative association between O and hospitalizations for gout (lag0, RR=0.986, 95% CI: 0.976-0.996). Stratified analyses showed that exposure to high levels of NO was considered to be more vulnerable to gout in cold season.

CONCLUSION

Our study showed that short-term exposure to NO and CO has a significant effect on hospitalizations for acute gout.

摘要

目的

痛风是一种由尿酸钠（MSU）晶体沉积引起的慢性疾病。关于环境危害与痛风之间关联的现有数据很少。本研究旨在调查2016年至2020年中国安庆市短期接触空气污染与急性痛风住院之间的关系。

方法

从安庆市三级甲等医院检索2016年1月1日至2020年12月31日安庆市急性痛风住院的每日记录。空气污染物和气象数据分别从中国环境监测站和中国气象数据服务中心获取。我们使用时间序列分析来探索空气污染（NO、O和CO）与急性痛风住院之间的关联，并按性别、年龄和季节进行分层分析。

结果

我们观察到NO与痛风住院之间存在关联（滞后0天，相对风险（RR）：1.022，95%置信区间（CI）：1.004 - 1.041）。CO浓度每增加1 mg/m，痛风住院人数增加3.9%（滞后11天，RR = 1.039，95% CI：1.004 - 1.076）。有趣的是，O与痛风住院之间存在负相关（滞后0天，RR = 0.986，95% CI：0.976 - 0.996）。分层分析表明，在寒冷季节，接触高水平的NO被认为更容易患痛风。

结论

我们的研究表明，短期接触NO和CO对急性痛风住院有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/503618af2f86/JIR-14-5827-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/cc66453ef79b/JIR-14-5827-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/ac0adc52a908/JIR-14-5827-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/d1e4624b2e94/JIR-14-5827-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/81d48c05c2b1/JIR-14-5827-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/70e314c3c4d2/JIR-14-5827-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/503618af2f86/JIR-14-5827-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/cc66453ef79b/JIR-14-5827-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/ac0adc52a908/JIR-14-5827-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/d1e4624b2e94/JIR-14-5827-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/81d48c05c2b1/JIR-14-5827-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/70e314c3c4d2/JIR-14-5827-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b6/8575452/503618af2f86/JIR-14-5827-g0006.jpg

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