Department of Occupational and Environmental Medicine, Ewha Womans University School of Medicine, Seoul 07985, Korea.
Department of Medical Science, Ewha Womans University School of Medicine, Seoul 07985, Korea.
Int J Environ Res Public Health. 2019 Apr 6;16(7):1227. doi: 10.3390/ijerph16071227.
Environmental factors may play roles in the development of rheumatoid arthritis (RA), and some studies have shown that air pollution was associated with the development of autoimmune disease. This study was designed to investigate the effect of air pollutants on the development of adult RA. A nested case-control cohort study was performed using the National Health Insurance Service-National Sample Cohort during 2002⁻2014 in Korea. Air pollution data were collected from the National Ambient Air Monitoring System (NAMIS), and exposure levels were extrapolated using geographic information systems. The group with RA ( = 444) was compared with a propensity score-matched control group ( = 1776), and one-year average concentrations of air pollution were predicted at each patient's residence. The adjusted binary logistic regression analysis showed a positive association between O₃ exposure and the incidence risk of RA for the third (odds ratios (OR) = 1.45, 95% confidence intervals (CI): 1.08⁻1.96) and fourth (OR = 1.35, 95% CI: 1.00⁻1.83) quartiles in adults over 20 years of age. The third quartile CO exposure was also associated with an increased risk of RA (OR = 1.57, 95% CI: 1.16⁻2.12). The results of this nationwide population-based study showed that a one-year exposure to CO and O₃ in adults was associated with an increased risk of RA.
环境因素可能在类风湿关节炎（RA）的发展中起作用，一些研究表明空气污染与自身免疫性疾病的发展有关。本研究旨在探讨空气污染物对成人 RA 发展的影响。本研究采用韩国 2002-2014 年国家健康保险服务-国家样本队列进行了一项巢式病例对照队列研究。空气污染数据来自国家环境空气监测系统（NAMIS），并使用地理信息系统推断暴露水平。RA 组（n=444）与倾向评分匹配的对照组（n=1776）进行比较，预测每位患者居住地的一年平均空气污染浓度。调整后的二元逻辑回归分析显示，O₃暴露与 20 岁以上成年人 RA 的发病风险呈正相关，第三（OR=1.45，95%CI：1.08-1.96）和第四（OR=1.35，95%CI：1.00-1.83）四分位组。暴露于 CO 的第三个四分位数也与 RA 风险增加相关（OR=1.57，95%CI：1.16-2.12）。这项全国性基于人群的研究结果表明，成年人一年接触 CO 和 O₃与 RA 风险增加有关。
