Xue Fengfeng, Qin Ruomeng, Zhu Runwei, Zhou Xiaoxia
Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.
School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
Dalton Trans. 2022 Dec 6;51(47):18169-18175. doi: 10.1039/d2dt02926j.
Sn species modified zeolite TS-1 with a unique mesopore structure (Sn-TS-1) and rich oxygen vacancy defects has been designed a sol-gel method and an ion-exchange process, which can be used as an enzyme-free electrochemical sensor for HO detection. The resultant composite Sn-TS-1 has a high BET surface area of 191 cm g, fast electron transfer, rich oxygen vacancies, and abundant active sites, showing super performance in HO reduction with a low detection limit (0.27 μM, S/N = 3). The current is linear with HO concentration from 1 to 1000 and 1000 to 11 000 μM, and the corresponding sensitivities are 360.4 and 80.44 μA mM cm, respectively. More importantly, this Sn-TS-1 sensor also shows excellent anti-interference ability and stability. This work provides a new idea for an enzyme-free sensor for HO detection in biological environments, which has promising potential in point-of-care (POC) testing for HO.
通过溶胶-凝胶法和离子交换过程设计出了具有独特介孔结构（Sn-TS-1）和丰富氧空位缺陷的锡物种修饰沸石TS-1，其可用作检测过氧化氢（HO）的无酶电化学传感器。所得的复合Sn-TS-1具有191 cm²/g的高比表面积、快速的电子转移、丰富的氧空位和大量活性位点，在过氧化氢还原方面表现出卓越性能，检测限低（0.27 μM，信噪比 = 3）。电流与过氧化氢浓度在1至1000 μM以及1000至11000 μM范围内呈线性关系，相应的灵敏度分别为360.4和80.44 μA mM⁻¹ cm⁻²。更重要的是，这种Sn-TS-1传感器还表现出出色的抗干扰能力和稳定性。这项工作为生物环境中检测过氧化氢的无酶传感器提供了新思路，在过氧化氢的即时检测（POC）中具有广阔的应用潜力。
