Ezzeddine Fatima M, Darlington Ashley M, DeSimone Christopher V, Asirvatham Samuel J
Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA.
Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA.
Card Electrophysiol Clin. 2022 Dec;14(4):729-742. doi: 10.1016/j.ccep.2022.06.002. Epub 2022 Oct 28.
Ventricular fibrillation (VF) is a common cause of sudden cardiac death (SCD) and is unfortunately without a cure. Current therapies focus on prevention of SCD, such as implantable cardioverter-defibrillator (ICD) implantation and anti-arrhythmic agents. Significant progress has been made in improving our understanding and ability to target the triggers of VF, via advanced mapping and ablation techniques, as well as with autonomic modulation. However, the critical substrate for VF maintenance remains incompletely defined. In this review, we discuss the evidence behind the basic mechanisms of VF and review the current role of catheter ablation in patients with VF.
心室颤动（VF）是心源性猝死（SCD）的常见原因，遗憾的是目前尚无治愈方法。当前的治疗重点是预防SCD，例如植入式心脏复律除颤器（ICD）植入和抗心律失常药物。通过先进的标测和消融技术以及自主神经调节，我们在了解和靶向VF触发因素的能力方面取得了重大进展。然而，维持VF的关键基质仍未完全明确。在本综述中，我们讨论了VF基本机制背后的证据，并回顾了导管消融在VF患者中的当前作用。
