Department of Geriatric Endocrinology and Metabolism, Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Gastroenterology and Thoracic Surgery, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Can J Gastroenterol Hepatol. 2022 Nov 8;2022:6799414. doi: 10.1155/2022/6799414. eCollection 2022.
The pathogenesis of NAFLD is complex and diverse, involving multiple signaling pathways and cytokines from various organs. Hepatokines, stellakines, adipokines, and myokines secreted by hepatocytes, hepatic stellate cells, adipose tissue, and myocytes play an important role in the occurrence and development of nonalcoholic fatty liver disease (NAFLD). The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) contributes to the progression of NAFLD by mediating liver inflammation, immune response, hepatocyte death, and later compensatory proliferation. In this review, we first discuss the crosstalk and interaction between hepatokines, stellakines, adipokines, and myokines and NF-B in NAFLD. The characterization of the crosstalk of NF-B with these factors will provide a better understanding of the molecular mechanisms involved in the progression of NAFLD. In addition, we examine new expert management opinions for NAFLD and explore the therapeutic potential of silymarin in NAFLD/NASH.
非酒精性脂肪性肝病（NAFLD）的发病机制复杂多样，涉及多个信号通路和来自不同器官的细胞因子。肝细胞、肝星状细胞、脂肪组织和肌细胞分泌的肝因子、星状因子、脂肪因子和肌因子在非酒精性脂肪性肝病（NAFLD）的发生和发展中起着重要作用。核因子 kappa 轻链增强子的 B 细胞（NF-B）通过介导肝脏炎症、免疫反应、肝细胞死亡和随后的代偿性增殖，促进 NAFLD 的进展。在这篇综述中，我们首先讨论了在 NAFLD 中肝因子、星状因子、脂肪因子和肌因子与 NF-B 之间的串扰和相互作用。NF-B 与这些因子的串扰特征将提供对 NAFLD 进展中涉及的分子机制的更好理解。此外，我们还检查了 NAFLD 的新专家管理意见，并探讨了水飞蓟素在 NAFLD/NASH 中的治疗潜力。
