Ardeshiri Hanieh, Ghorbani Mina, Nazarinia Mohammad Ali, Falamarzi Kimia, Tamaddon Ali Mohammad, Azarpira Negar
Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz, Iran.
Chemical Engineering Department, University of Waterloo, Waterloo, Ontario, Canada.
J Cell Mol Med. 2025 Jul;29(14):e70478. doi: 10.1111/jcmm.70478.
Skin fibrosis in scleroderma is a chronic and debilitating condition that affects the quality of life of patients. In this study, we fabricated a niosomal hydrogel containing bromelain to reduce skin collagen and improve skin softness in scleroderma patients. The niosomes were prepared using the thin film hydration method and exhibited a drug loading efficiency of 52.2%. They demonstrated high monodispersity, with mean sizes lower than 200 nm. The results showed a significant reduction in mean dermal thickness from 1195 μm before treatment to 750 μm after the 2-month treatment period. This reduction in dermal thickness and improved skin softness can be attributed to the decomposition of accumulated skin collagen in individuals with scleroderma. Additionally, the treatment was found to be effective in reducing skin collagen levels compared to conventional treatment options that merely impede collagen synthesis. The current study underscores the potential of bromelain niosomal hydrogel as a promising strategy for managing skin fibrosis in scleroderma.
硬皮病中的皮肤纤维化是一种慢性且使人衰弱的病症，会影响患者的生活质量。在本研究中，我们制备了一种含有菠萝蛋白酶的非离子型脂质体水凝胶，以减少硬皮病患者的皮肤胶原蛋白并改善皮肤柔软度。非离子型脂质体采用薄膜水化法制备，载药效率为52.2%。它们表现出高单分散性，平均尺寸小于200nm。结果显示，治疗前平均真皮厚度为1195μm，经过2个月的治疗期后降至750μm，有显著降低。真皮厚度的这种降低以及皮肤柔软度的改善可归因于硬皮病患者体内积累的皮肤胶原蛋白的分解。此外，与仅阻碍胶原蛋白合成的传统治疗方案相比，该治疗方法在降低皮肤胶原蛋白水平方面被发现是有效的。当前研究强调了菠萝蛋白酶非离子型脂质体水凝胶作为治疗硬皮病皮肤纤维化的一种有前景策略的潜力。
