Li Ying, Qin Chuan, Dong Lezhen, Zhang Xin, Wu Zufang, Liu Lingyi, Yang Junsi, Liu Lianliang
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang, School of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, Zhejiang, PR China.
Department of food science and technology, University of Lincoln, Nebraska, USA.
Food Funct. 2022 Dec 13;13(24):12686-12696. doi: 10.1039/d2fo01746f.
Increasing evidence has confirmed that whole grain oats are effective in regulating hyperlipidemia. However, which specific ingredient is crucial remains unclear. This study focused on which whole grain components, oat phenolic compounds (OPC) or oat β-glucan (OBG), can regulate lipid metabolism and gut microbiota. The experiment unveiled that OPC and/or OBG not only reduced the body weight and fasting blood glucose (FBG) but also regulated serum and hepatic lipid levels in high-fat-diet (HFD) fed mice. There was no significant difference in the regulatory effects of OPC and OBG ( > 0.05). The combination of OPC and OBG (OPC + OBG) significantly decreased the body weight ( < 0.01) and reduced the blood glucose ( < 0.01) and lipid profile levels ( < 0.01). The real-time quantitative PCR (RT-qPCR) study revealed that OPC + OBG significantly altered mRNA expression related to lipid metabolism. Histopathological analysis showed that OPC + OBG improved liver lipid deposition as well as liver oxidative stress ( < 0.05). In addition, OPC + OBG combination regulated the gut microbiota community phenotype and increased probiotics. OPC + OBG significantly increased the abundance of and reduced the abundance of ( < 0.05) compared with the OPC and OBG fed mice. In conclusion, OPC + OBG has a synergistic effect in alleviating hyperlipidemia lipid metabolism and gut microbiota composition. This finding also provided a potential justification for the advantages of whole grains in preventing hyperlipidemia.
越来越多的证据证实，全谷物燕麦在调节高脂血症方面是有效的。然而，哪种特定成分至关重要仍不清楚。本研究聚焦于全谷物的哪些成分，即燕麦酚类化合物（OPC）或燕麦β-葡聚糖（OBG），能够调节脂质代谢和肠道微生物群。实验表明，OPC和/或OBG不仅降低了高脂饮食（HFD）喂养小鼠的体重和空腹血糖（FBG），还调节了血清和肝脏脂质水平。OPC和OBG的调节作用没有显著差异（>0.05）。OPC与OBG的组合（OPC + OBG）显著降低了体重（<0.01），降低了血糖（<0.01）和脂质谱水平（<0.01）。实时定量PCR（RT-qPCR）研究表明，OPC + OBG显著改变了与脂质代谢相关的mRNA表达。组织病理学分析表明，OPC + OBG改善了肝脏脂质沉积以及肝脏氧化应激（<0.05）。此外，OPC + OBG组合调节了肠道微生物群群落表型并增加了益生菌。与喂食OPC和OBG的小鼠相比，OPC + OBG显著增加了[具体菌种1]的丰度并降低了[具体菌种2]的丰度（<0.05）。总之，OPC + OBG在缓解高脂血症、脂质代谢和肠道微生物群组成方面具有协同作用。这一发现也为全谷物在预防高脂血症方面的优势提供了潜在的依据。
