Guo Haodong, Yi Jingsong, Wang Fan, Lei Tong, Du Hongwu
School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, China; Daxing Research Institute, University of Science and Technology Beijing, Beijing, 100083, China.
Neurochem Int. 2023 Jan;162:105453. doi: 10.1016/j.neuint.2022.105453. Epub 2022 Nov 17.
Parkinson's disease (PD) is a common chronic neurodegenerative disease, and the heat shock proteins (HSPs) are proved to be of great value for PD. In addition, HSPs can maintain protein homeostasis, degrade and inhibit protein aggregation by properly folding and activating intracellular proteins in PD. This study mainly summarizes the important roles of HSPs in PD and explores their feasibility as targets. We introduced the structural and functional characteristics of HSPs and the physiological functions of HSPs in PD. HSPs can protect neurons from damage by degrading aggregates with three mechanisms, including the aggregation and removing α-Synuclein (α-Syn) aggregates, promotion the autophagy of abnormal proteins, and inhibition the apoptosis of degenerated neurons. This study underscores the importance of HSPs as targets in PD and helps to expand new mechanisms in PD treatment strategies.
帕金森病（PD）是一种常见的慢性神经退行性疾病，热休克蛋白（HSPs）已被证明对帕金森病具有重要价值。此外，热休克蛋白可通过在帕金森病中正确折叠和激活细胞内蛋白质来维持蛋白质稳态、降解并抑制蛋白质聚集。本研究主要总结了热休克蛋白在帕金森病中的重要作用，并探讨了其作为靶点的可行性。我们介绍了热休克蛋白的结构和功能特征以及热休克蛋白在帕金森病中的生理功能。热休克蛋白可通过三种机制降解聚集体来保护神经元免受损伤，包括聚集和清除α-突触核蛋白（α-Syn）聚集体、促进异常蛋白质的自噬以及抑制退化神经元的凋亡。本研究强调了热休克蛋白作为帕金森病靶点的重要性，并有助于拓展帕金森病治疗策略的新机制。
