Clinical and Research Department of Applied Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawińskiego Street, 02-106, Warsaw, Poland.
Sci Rep. 2022 Nov 19;12(1):19940. doi: 10.1038/s41598-022-17439-x.
The aim of the study was to reveal whether marathon running influences regulators of lipid metabolism i.e. angiopoietin-like protein 4 (ANGPTL4), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α). Plasma concentration of ANGPTL4, IL-6, TNF-α and lipids were determined in samples collected from 11 male runners before the marathon, immediately after the run and at 90 min of recovery. Plasma ANGPTL4 increased during exercise from 55.5 ± 13.4 to 78.1 ± 15.0 ng/ml (P < 0.001). This was accompanied by a significant increase in IL-6, TNF-α, free fatty acids (FFA) and glycerol (Gly) and a decrease in triacylglycerols (TG). After 90 min of recovery ANGPTL4 and TG did not differ from the exercise values, while plasma IL-6, TNF-α, FFA and Gly concentration were significantly lower. The exercise-induced increase in plasma concentration of ANGPTL4 correlated positively with the rise in plasma IL-6, TNF-α, FFA and Gly and negatively with the duration of the run. The increase in plasma IL-6 and TNF-α correlated positively with the rise in Gly. Summarizing, marathon running induced an increase in plasma ANGPTL4 and the value was higher in faster runners. The increase in plasma FFA, IL-6 and TNF-α concentration during a marathon run may be involved in plasma ANGPTL4 release, which could be a compensatory mechanism against FFA-induced lipotoxicity and oxidative stress. All of the analyzed cytokines may stimulate lipolysis during exercise.
这项研究的目的是揭示马拉松跑步是否会影响脂代谢调节剂，即血管生成素样蛋白 4（ANGPTL4）、白细胞介素 6（IL-6）和肿瘤坏死因子-α（TNF-α）。在马拉松比赛前、跑步后立即和恢复 90 分钟时，从 11 名男性跑步者身上采集样本，测定血浆中 ANGPTL4、IL-6、TNF-α 和脂质的浓度。运动过程中，血浆 ANGPTL4 从 55.5±13.4ng/ml 增加到 78.1±15.0ng/ml（P<0.001）。这伴随着 IL-6、TNF-α、游离脂肪酸（FFA）和甘油（Gly）的显著增加以及三酰甘油（TG）的减少。恢复 90 分钟后，ANGPTL4 和 TG 与运动值无差异，而血浆 IL-6、TNF-α、FFA 和 Gly 浓度明显降低。运动引起的血浆 ANGPTL4 浓度升高与血浆 IL-6、TNF-α、FFA 和 Gly 的升高呈正相关，与跑步时间呈负相关。血浆 IL-6 和 TNF-α 的增加与 Gly 的升高呈正相关。总之，马拉松跑步引起血浆 ANGPTL4 增加，且在跑步速度较快的人中增加更为明显。马拉松跑期间 FFA、IL-6 和 TNF-α 浓度的增加可能参与了血浆 ANGPTL4 的释放，这可能是一种对 FFA 诱导的脂毒性和氧化应激的补偿机制。所有分析的细胞因子都可能在运动期间刺激脂肪分解。
