Saleh Muhammad H A, Decker Ann, Wang Hom-Lay
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
J Periodontol. 2023 Mar;94(3):311-312. doi: 10.1002/JPER.22-0475. Epub 2023 Jan 17.
To achieve the ultimate therapeutic reality of disease prevention, we must first conduct a thorough review of periodontal and peri-implant diseases concomitant with their mechanistic, predisposing, and precipitating factors to address the present oral/systemic needs of our patients.
An innovative dental research patient data repository (RPDR) named BigMouth was successfully launched in August 2012 with data on more than 4.5 million patients seen in 11 dental schools (members of the Consortium of Oral Health Research and Informatics, COHRI).
Level 1 data access allots researchers with count data that may be used to formulate and test initial hypotheses based on preliminary data trends. Level 2 access gives more detailed, patient-level information with full periodontal charts. Of note, radiographic data were not accessible at the time of writing this manuscript.
As we support the use of these innovative "big data" tools for exploratory use, we bring to the forefront the purposeful intention to (1) not overproject unsubstantiated relationships and (2) simultaneously pursue grounding of the mechanistic underpinnings of found associations.
为实现疾病预防的最终治疗目标，我们必须首先全面回顾牙周病和种植体周围疾病，并了解其机制、易感因素和诱发因素，以满足患者当前的口腔/全身需求。
一个名为“大嘴”的创新型牙科研究患者数据存储库（RPDR）于2012年8月成功启动，其中包含11所牙科学院（口腔健康研究与信息学联盟成员，COHRI）诊治的450多万患者的数据。
一级数据访问为研究人员提供计数数据，可用于根据初步数据趋势制定和检验初始假设。二级访问提供更详细的患者级信息以及完整的牙周检查表。值得注意的是，在撰写本文时无法获取放射学数据。
在我们支持使用这些创新的“大数据”工具进行探索性研究的同时，我们将以下有目的的意图置于首位：（1）不过度推测未经证实的关系；（2）同时寻求对已发现关联的机制基础进行深入研究。
