Role of mA modification in dysregulation of Wnt/β-catenin pathway in cancer.

N6-methyladenosine (mA) modification is the most abundant post-transcriptional regulation of RNAs in eukaryotes. Dysregulation of mA readers, writers, and erasers can significantly promote tumorigenesis by altering the expression of various genes. Wnt/β-catenin is an evolutionarily conserved signaling pathway that has recently been linked to the pathogenesis of many cancers. Given the significance of this pathway in regulating normal tissue homeostasis and stem cell differentiation, a subtle understanding of the molecular mechanism underlying its dysregulation is required for effective targeting. There is mounting evidence that mA regulators are highly implicated in the dysregulation of the Wnt/β-catenin signaling pathway. Since mA regulators can affect Wnt pathway components and dysregulation of either leads to carcinogenesis, this study aims to clarify the relationship between mA regulators and the Wnt/β-catenin signaling pathway to investigate their combined impact on tumorigenesis.