Ruan X
Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China.
Gynecol Endocrinol. 2023 Dec;39(1):2146671. doi: 10.1080/09513590.2022.2146671. Epub 2022 Nov 20.
Preconditioning before hematopoietic stem cell transplantation (HSCT) seriously damages the ovarian function and causes female infertility. This consensus focuses on the fertility preservation(FP) for girls needing HSCT, aim to make doctors in different disciplines aware of the importance, necessity and technique of ovarian protection. Summarizing relevant literature and organizing multidisciplinary experts, including obstetrics and gynecology, reproductive medicine, oncology, pediatrics and hematology for full discussion. Individuals exposed to HSCT in childhood are at higher risk of loss of fertility. Considering the high risk of premature ovarian insufficiency (POI) after conditioning and negative impact of POI on fertility, physical and mental health, it is absolutely necessary to protect fertility before HSCT conditioning. Ovarian tissue cryopreservation is the main fertility preservation option for these population. Fertility preservation before HSCT conditioning is crucial. Ovarian tissue cryopreservation is often the only option for these population.
造血干细胞移植（HSCT）前的预处理会严重损害卵巢功能并导致女性不孕。本共识聚焦于需要进行HSCT的女孩的生育力保存（FP），旨在让不同学科的医生了解卵巢保护的重要性、必要性和技术。总结相关文献并组织多学科专家，包括妇产科、生殖医学、肿瘤学、儿科学和血液学专家进行充分讨论。童年期接受HSCT的个体生育力丧失风险更高。考虑到预处理后卵巢早衰（POI）的高风险以及POI对生育力、身心健康的负面影响，在HSCT预处理前保护生育力绝对必要。卵巢组织冷冻保存是这些人群主要的生育力保存选择。HSCT预处理前的生育力保存至关重要。卵巢组织冷冻保存通常是这些人群的唯一选择。
