The Fertility Department, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
The Laboratory of Reproductive Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Mult Scler Relat Disord. 2023 Jun;74:104716. doi: 10.1016/j.msard.2023.104716. Epub 2023 Apr 11.
Women of fertile age who receive autologous hematopoietic stem cell transplantation (AHSCT) due to multiple sclerosis (MS) are at risk of loss of ovarian function and infertility because of the conditioning regimen with alkylating agents.
To present our data on fertility preservation by ovarian tissue cryopreservation (OTC) in young women with MS before AHSCT.
Retrospective, observational cohort study RESULTS: Eight women had OTC. After AHSCT four had premature ovarian insufficiency (POI), and two of these had autotransplantation of their cryopreserved ovarian tissue. Both women regained ovarian function, and a spontaneous pregnancy was achieved resulting in the delivery of a healthy baby.
OTC preserves fertility in young women with MS at risk of POI.
由于多发性硬化症（MS），许多育龄妇女需要接受自体造血干细胞移植（AHSCT），而烷化剂预处理方案可能导致卵巢功能丧失和不孕。
介绍我们在 AHSCT 前对年轻 MS 女性进行卵巢组织冷冻保存（OTC）以保留生育力的数据。
回顾性观察性队列研究。
8 名女性进行了 OTC。AHSCT 后，4 名女性发生了卵巢早衰（POI），其中 2 名接受了冷冻卵巢组织的自体移植。这两名女性均恢复了卵巢功能，并自然妊娠，成功分娩了一名健康婴儿。
OTC 可保留 MS 高危 POI 年轻女性的生育能力。
