Sheng Yuze, Chen Zhongjian, Wu Wei, Lu Yi
Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai, China.
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200433, China; Shanghai Engineering Research Center For External Chinese Medicine, Shanghai 200433, China.
Drug Discov Today. 2023 Feb;28(2):103455. doi: 10.1016/j.drudis.2022.103455. Epub 2022 Nov 17.
Biofilms are colonies of microorganisms that are embedded in autocrine extracellular polymeric substances (EPS), imparting antibiotic resistance and recalcitrant bacterial infection. Nanoparticles (NPs) can enhance the biofilm inhibition and eradication of delivered antibiotics. This is mainly because of enhanced EPS penetration and a high local drug concentration. As we discuss here, novel strategies are being developed to further enhance the antibiofilm capacity of NPs, including size optimization, surface modification, stimuli-triggered release, and combined strategies. Thus, NPs represent an effective and promising approach to combat biofilms.
生物膜是嵌入自分泌胞外聚合物（EPS）中的微生物菌落，具有抗生素抗性和顽固性细菌感染。纳米颗粒（NPs）可以增强生物膜对递送抗生素的抑制和根除作用。这主要是因为增强了对EPS的渗透和提高了局部药物浓度。正如我们在此所讨论的，正在开发新的策略以进一步增强纳米颗粒的抗生物膜能力，包括尺寸优化、表面修饰、刺激触发释放和联合策略。因此，纳米颗粒是对抗生物膜的一种有效且有前景的方法。
