State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming 650500, People's Republic of China.
Fitoterapia. 2023 Jan;164:105356. doi: 10.1016/j.fitote.2022.105356. Epub 2022 Nov 18.
A phytochemical investigation of the whole plants of T. delavayi led to the isolation of five new dimeric benzylisoquinoline alkaloids, thalidelavines A-E (1-5), together with six known congeners (6-11). The structures and absolute configurations of new compounds were established based on analyses of spectroscopic data, ECD calculations, and single crystal X-ray crystallography. Thalidelavines A-E (1-5) were structurally complex bisbenzylisoquinoline alkaloids with various configurations. These isolated alkaloids were evaluated for their cytotoxic and immunosuppressive effects. Among them, both 9 and 10 displayed significant cytotoxicities against T98G cell lines with an IC value of 2.1 μM, compared with the positive CPT-11 (IC = 3.0 μM). In addition, 5-7 showed remarkable immunosuppressive effects. These findings not only enrich the structural diversity of bisbenzylisoquinoline alkaloids, but also provide potential candidates for the further development of the antitumor and immunosuppressive agents.
对滇藏黄连全植物的植物化学研究导致分离出五个新的二聚体苄基异喹啉生物碱，即滇藏黄连 A-E（1-5），以及六个已知的同系物（6-11）。新化合物的结构和绝对构型是基于光谱数据分析、ECD 计算和单晶 X 射线晶体学分析确定的。滇藏黄连 A-E（1-5）是具有各种结构的复杂双苄基异喹啉生物碱。对这些分离得到的生物碱进行了细胞毒性和免疫抑制作用的评价。其中，9 和 10 对 T98G 细胞系的细胞毒性作用显著，IC 值为 2.1 μM，与阳性对照 CPT-11（IC = 3.0 μM）相比。此外，5-7 还表现出显著的免疫抑制作用。这些发现不仅丰富了双苄基异喹啉生物碱的结构多样性，而且为进一步开发抗肿瘤和免疫抑制剂提供了潜在的候选药物。
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