Department of Child, Family, and Population Health Nursing, School of Nursing, University of Washington, Seattle, WA, USA.
Department of Physical Education, Londrina State University, Londrina, Brazil.
AIDS Care. 2023 Dec;35(12):1863-1873. doi: 10.1080/09540121.2022.2147482. Epub 2022 Nov 20.
This study examined the factors associated with low muscle strength, muscle mass, and physical performance in 331 people living with HIV. Participants completed handgrip as a strength measure, appendicular skeletal muscle mass using bioimpedance analysis, and chair rise was a physical performance measure. Multivariate logistic regression was used to analyze the association between low values on these measures with sociodemographic, HIV-related factors, and comorbidities. Higher body mass index (BMI) (OR = 0.91; CI = 0.86-0.97) and higher CD4/CD8 ratio (OR = 0.38; 95% CI = 0.18-0.82) were associated with decreased likelihood of low handgrip strength. Being non-employed (OR = 2.08; 95% CI = 1.07-4.06), having hypertension (OR = 2.27; 95% CI = 1.13-4.54) and rheumatism (OR = 5.46; 95% CI = 1.68-17.74) increased the chance of low handgrip strength. Higher BMI (OR = 0.43; 95% CI = 0.34-0.56), CD4/CD8 ratio (OR = 0.29; 95% CI = 0.09-0.93), and bioimpedance phase angle (OR = 0.22; 95% CI = 0.12-0.40) were associated with decreased likelihood of low muscle mass. Lastly, having less than eight years of education (OR = 1.87; 95% CI = 1.02-3.41) and being non-employed (OR = 8.18; 95% CI = 3.09-21.61) increased the chance of low chair stand performance. In addition, higher CD4 + lymphocytes count (OR = 0.99; 95% CI = 0.99-0.99) was associated with a decreased likelihood of low chair stand performance. In conclusion, specific and non-specific HIV-related factors are associated with low handgrip strength, low muscle mass, and/or low chair stand performance.
本研究调查了 331 名 HIV 感染者中与肌肉力量低下、肌肉量和身体表现相关的因素。参与者完成了握力作为力量测量，使用生物电阻抗分析测量四肢骨骼肌量，以及椅子站立作为身体表现测量。多变量逻辑回归用于分析这些测量值低值与社会人口统计学、HIV 相关因素和合并症之间的关联。较高的体重指数（BMI）（OR=0.91；95%CI=0.86-0.97）和较高的 CD4/CD8 比值（OR=0.38；95%CI=0.18-0.82）与较低的握力降低可能性相关。非就业（OR=2.08；95%CI=1.07-4.06）、高血压（OR=2.27；95%CI=1.13-4.54）和风湿症（OR=5.46；95%CI=1.68-17.74）增加了握力降低的可能性。较高的 BMI（OR=0.43；95%CI=0.34-0.56）、CD4/CD8 比值（OR=0.29；95%CI=0.09-0.93）和生物电阻抗相角（OR=0.22；95%CI=0.12-0.40）与较低的肌肉量低值可能性相关。最后，受教育程度不足八年（OR=1.87；95%CI=1.02-3.41）和非就业（OR=8.18；95%CI=3.09-21.61）增加了椅子站立表现不佳的机会。此外，较高的 CD4+淋巴细胞计数（OR=0.99；95%CI=0.99-0.99）与较低的椅子站立表现可能性相关。总之，特定和非特定的 HIV 相关因素与握力降低、肌肉量降低和/或椅子站立表现降低有关。
