Coombe Women and Infant University Hospital, Dublin 8, Ireland.
Fetal Medicine Unit, Liverpool Women's Hospital, Liverpool, UK; Fetal Medicine Unit, St George's Hospital, London, UK; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK; Twins Trust Centre for Research and Clinical Excellence, St George's Hospital, London, UK.
Best Pract Res Clin Obstet Gynaecol. 2022 Nov;84:205-217. doi: 10.1016/j.bpobgyn.2022.08.009. Epub 2022 Sep 29.
Twins have a significantly higher risk of stillbirth, preterm delivery, perinatal morbidity and mortality. Single intrauterine fetal death is a relatively common and devastating occurrence for families and clinicians alike. Monochorionic twins are up to 13 times more likely to suffer an intrauterine death when compared to singletons. Additionally, longer term neurological sequelae affect monochorionic twins disproportionately. The timing of the death of the co-twin and the fetal order at the time of death have an impact on the outcome for the survivor. The risk in dichorionic pregnancies is lower with respect to neurological injury; however, the risk of prematurity remains high, particularly where the leading twin dies in utero. Recent published studies report lower rates of neurological injury in monochorionic twin pregnancies that incur an intrauterine fetal death after foetoscopic laser ablation for twin-to-twin transfusion syndrome - an important finding for patient counselling. TWEETABLE ABSTRACT: Single intrauterine fetal death in twins is a relatively common and devastating occurrence for families and clinicians alike. Adhering to collegiate guidelines will likely reduce but not eliminate the incidence of SIUD in twins.
双胞胎的死产、早产、围产期发病率和死亡率显著增加。单胎胎儿宫内死亡对家庭和临床医生来说都是一种相对常见且具有破坏性的事件。与单胎相比,单绒毛膜双胞胎宫内死亡的风险增加了 13 倍。此外,单绒毛膜双胞胎的长期神经后遗症不成比例地影响。双胞胎死亡的时间和死亡时的胎儿顺序对幸存者的结局有影响。双绒毛膜妊娠的神经损伤风险较低,但早产风险仍然很高,尤其是当主要胎儿在子宫内死亡时。最近发表的研究报告称,在胎儿镜激光消融治疗双胎输血综合征后发生宫内胎儿死亡的单绒毛膜双胞胎妊娠中,神经损伤的发生率较低,这对患者咨询是一个重要发现。