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20-21 孕周一胎死宫内的单绒毛膜性双胎妊娠的保守治疗及第二胎成功足月分娩

Conservative Management of a Monochorionic Twin Pregnancy with an Intrauterine Fetal Death at 20-21 Weeks and Successful Term Delivery of the Second Twin.

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, West Java, Indonesia.

出版信息

Am J Case Rep. 2024 Jul 27;25:e942321. doi: 10.12659/AJCR.942321.

DOI:10.12659/AJCR.942321
PMID:39066470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11299885/
Abstract

BACKGROUND One of the obstetric complications of twin pregnancy was the intrauterine death of one fetus. The death that occurs in the first trimester usually leads to fewer complications than the death in the second and third trimester. In the second and third trimesters, single fetal death of twin pregnancy was reported to increase the death, preterm birth, and neurological injury of the surviving co-twin. Although rare, it might trigger a coagulation defect in the mother as well. Neurological morbidities were also more common in monochorionic twins than in dichorionic gestation. Thus, a consideration of pregnancy termination might persist. CASE REPORT We present a case of a primigravida with a monochorionic twin pregnancy whose intrauterine death of one fetus at 20-21 weeks of gestation. We managed this patient with pregnancy continuation under close monitoring more than 12 weeks until she delivered the surviving one at term. The outcome of the surviving baby was normal condition and appropriate weight, no fetal morbidity, and no maternal morbidity related to coagulation disorder in the mother. CONCLUSIONS Conservative management under close monitoring until term in monochorionic twin pregnancy with single fetal death could be the best option to obtain a favorable outcome. We recommend conservative management with close surveillance monitoring using non-stress tests after 32 weeks, biweekly ultrasound, and at least of one maternal coagulation profile test.

摘要

背景

双胎妊娠的产科并发症之一是胎儿宫内死亡。妊娠早期发生的死亡通常比妊娠中期和晚期发生的死亡并发症少。在妊娠中期和晚期,据报道,双胎妊娠的单一胎儿死亡会增加存活的同胞胎儿的死亡、早产和神经损伤的风险。尽管罕见,但它也可能引发母亲的凝血缺陷。神经发育障碍在单绒毛膜双胎中也比双绒毛膜妊娠更为常见。因此,可能会持续考虑终止妊娠。

病例报告

我们报告了一例初产妇,在妊娠 20-21 周时发生单绒毛膜双胎妊娠的一胎宫内死亡。我们对该患者进行了密切监测下的妊娠继续管理,超过 12 周,直到她足月分娩存活的一胎。存活婴儿的结局为正常状况和适当的体重,无胎儿畸形,也无与母亲凝血障碍相关的母体并发症。

结论

对于单绒毛膜双胎妊娠中出现单一胎儿死亡,在密切监测下进行保守管理直至足月可能是获得良好结局的最佳选择。我们建议在妊娠 32 周后进行密切监测,使用非应激试验、每两周进行一次超声检查以及至少进行一次母体凝血谱检查,以进行保守管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33a3/11299885/3789c74ddc04/amjcaserep-25-e942321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33a3/11299885/3789c74ddc04/amjcaserep-25-e942321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33a3/11299885/3789c74ddc04/amjcaserep-25-e942321-g001.jpg

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本文引用的文献

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Single intrauterine death in twin pregnancy: Evidenced-based counselling and management.双胎妊娠一胎宫内死亡:基于证据的咨询和管理。
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Monochorionic pseudomonoamniotic twin pregnancy with fetal demise of one twin and development of maternal consumptive coagulopathy.单绒毛膜假单羊膜双胎妊娠,其中一个胎儿死亡,并发生母体消耗性凝血病。
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