Khoshnevisan Kamyar, Chehrehgosha Maryam, Sajjadi-Jazi Sayed Mahmoud, Meftah Amir Mohammad
Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 1983963113 Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1983963113 Iran.
J Diabetes Metab Disord. 2022 Jul 18;21(2):1923-1934. doi: 10.1007/s40200-022-01096-y. eCollection 2022 Dec.
Alterations in the serotonergic system were verified to act a role in the pathogenesis of altered neurological and psychiatric diseases. In recent years, Tryptophan (Trp) and serotonin (5-HT) levels have been considered potent biomarkers of diabetes mellitus (DM).
The different Trp metabolism may also play roles in the pathogenesis of DM and mounting risk of complications. The whole blood (WB) 5-HT level was mainly lower among diabetic patients compared to others. That is mostly derived from a lower platelet concentration of 5-HT in these patients.
Indeed, 5-HT level can be considered a potent biomarker for early detection of DM complications. Besides, it was proved that outside the digestive and central nervous systems, 5-HT was discovered in beta cells, and scientists have been attempting to realize its mechanism of action ever since. Towards to end, the determination methods, biomarker's role, and approaches of 5-HT and Trp levels were thoroughly investigated in both healthy and diabetic patients with or without complications. Moreover, the association between insulin and 5-HT has been specifically discussed.
Our study concluded that Trp and 5-HT levels could be exclusively applied for early diagnosis of DM complications as well as many other complications.
血清素能系统的改变被证实与神经和精神疾病的发病机制有关。近年来，色氨酸（Trp）和血清素（5-HT）水平被认为是糖尿病（DM）的有效生物标志物。
不同的色氨酸代谢可能在糖尿病发病机制和并发症风险增加中起作用。与其他人相比，糖尿病患者的全血（WB）5-HT水平主要较低。这主要源于这些患者血小板中5-HT浓度较低。
事实上，5-HT水平可被视为早期发现糖尿病并发症的有效生物标志物。此外，已证明在消化系统和中枢神经系统之外，在β细胞中发现了5-HT，从那时起科学家们一直在试图了解其作用机制。最后，对有或无并发症的健康和糖尿病患者的5-HT和Trp水平的测定方法、生物标志物的作用及研究方法进行了深入研究。此外，还特别讨论了胰岛素与5-HT之间的关联。
我们的研究得出结论，色氨酸和5-HT水平可专门用于糖尿病并发症以及许多其他并发症的早期诊断。
