Rilwan Hadiza Bello, Adebisi Sunday Samuel, Timbuak James Abrak, Oladele Sunday Blessing, Muhammad Aliyu, Sadeeq Adamu Abubakar, Makena Wusa
Department of Human Anatomy, Kaduna State University, Kaduna, Kaduna State Nigeria.
Department of Human Anatomy, Ahmadu Bello University, Zaria, Kaduna State Nigeria.
J Diabetes Metab Disord. 2022 Sep 16;21(2):1625-1634. doi: 10.1007/s40200-022-01112-1. eCollection 2022 Dec.
The purpose of the study was to determine how camel milk affects hyperglycemia, beta-cell function, oxidative stress, and inflammatory markers in type 2 diabetic pigs.
Twenty-five (25) pigs were separated into five (5) groups of five pigs each, with five (5) non-diabetic and twenty (20) diabetic pigs in each group. Groups 1 and 2 received distilled water as the standard control and diabetic control groups, respectively, while Groups 3 and 4 received camel milk at 250 mL/day and 500 mL/day, respectively, and Group 5 received metformin at 500 mg/day. The experiment lasted ten weeks. At the end of the ten weeks, all the pigs were euthanized.
Treatments with camel milk substantially enhance glucose fasting levels by reducing hyperglycemia in diabetic pigs, significant level at (p < 0.05). When pigs given camel milk were compared with untreated diabetic pigs, there was a substantial rise (p < 0.05) in superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels. Also, camel milk substantially lowered the levels of interleukin (IL-1β) and tumour necrosis factor-alpha (TNF-α) in diabetic pig serum. Similarly, immunohistochemical analysis of islet cells revealed an increase in insulin production, implying improved glycemic control and the eventual commitment of glucose to glycolysis.
The bioactive-mediated anti-hyperglycemic and insulin release potential of camel milk treatments contributed to improving type 2 diabetes mellitus. Camel milk improved beta-cell function while reducing oxidative stress and inflammation in type 2 diabetic pigs.
本研究的目的是确定骆驼奶如何影响2型糖尿病猪的高血糖、β细胞功能、氧化应激和炎症标志物。
25头猪被分成5组，每组5头猪，每组中有5头非糖尿病猪和20头糖尿病猪。第1组和第2组分别接受蒸馏水作为标准对照组和糖尿病对照组，而第3组和第4组分别接受每天250毫升和500毫升的骆驼奶，第5组接受每天500毫克的二甲双胍。实验持续了十周。在十周结束时，所有的猪都被安乐死。
用骆驼奶治疗可通过降低糖尿病猪的高血糖水平，显著提高空腹血糖水平（p<0.05）。将给予骆驼奶的猪与未治疗的糖尿病猪进行比较时，超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和还原型谷胱甘肽（GSH）水平显著升高（p<0.05）。此外，骆驼奶显著降低了糖尿病猪血清中白细胞介素（IL-1β）和肿瘤坏死因子-α（TNF-α）的水平。同样，胰岛细胞的免疫组织化学分析显示胰岛素产量增加，这意味着血糖控制得到改善，葡萄糖最终进入糖酵解过程。
骆驼奶治疗具有生物活性介导的抗高血糖和胰岛素释放潜力，有助于改善2型糖尿病。骆驼奶改善了2型糖尿病猪的β细胞功能，同时降低了氧化应激和炎症反应。
