Zeng Qiao-Zhu, Li Si-Ying, Yao Yu-Ou, Jin En-Zhong, Qu Jin-Feng, Zhao Ming-Wei
Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People's Hospital, Beijing 100044, China.
Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China.
Int J Ophthalmol. 2022 Nov 18;15(11):1798-1805. doi: 10.18240/ijo.2022.11.10. eCollection 2022.
To compare ultra-widefield (24×20 mm) swept-source optical coherence tomography angiography (SS-OCTA) and fluorescein angiography (FA) in the evaluation of diabetic retinopathy (DR) lesions.
Forty-six eyes of 23 patients with treatment-naïve DR were included at Peking University People's Hospital from September 1, 2021, until December 31, 2021, as well as 23 age and gender matched healthy controls. Quantitative assessments of DR lesions on FA and SS-OCTA (superficial capillary plexus, SCP, 24×20 mm) were performed.
Area of fovea avascular zone (FAZ) was larger in DR cases than controls (0.34±0.069 mm 0.287±0.108 mm, =0.006). In DR eyes, the mean FAZ area was 0.34±0.069 and 0.334±0.087 mm on SS-OCTA and FA, respectively (=0.428), while the median FAZ perimeter was 2.382 (IQR, 2.201-2.59) and 2.333 (IQR, 2.138-2.6) mm on SS-OCTA and FA images (=0.733). There was no significant difference in the size of the non-perfusion area (NPA) between the images on SS-OCTA and FA (12.389, IQR 4.96-28.3 and 11.125, IQR 5-28.31 mm, =0.197). The median total microaneurysm (MA) count was 35 (IQR, 19-46) and 73 (IQR, 43-93) on SS-OCTA and FA (<0.001), respectively. No significant difference in intra-retinal microvascular abnormality (IRMA) and neovascularization (NV) count was found between the two techniques. The intraclass coefficient (ICCs) of all the parameters above indicated stable repeatability.
Ultra-widefield SS-OCTA represents a reliable, noninvasive, and quantitative imaging technique in the assessment of microvasculature in DR, which offers a potential substitute for FA in DR evaluation.
比较超广角（24×20mm）扫频光学相干断层扫描血管造影（SS-OCTA）和荧光素血管造影（FA）在评估糖尿病视网膜病变（DR）病变中的应用。
2021年9月1日至2021年12月31日，北京大学人民医院纳入了23例未经治疗的DR患者的46只眼，以及23名年龄和性别匹配的健康对照者。对FA和SS-OCTA（浅表毛细血管丛，SCP，24×20mm）上的DR病变进行定量评估。
DR病例的黄斑无血管区（FAZ）面积大于对照组（0.34±0.069mm对0.287±0.108mm，P=0.006）。在DR眼中，SS-OCTA和FA上的平均FAZ面积分别为0.34±0.069和0.334±0.087mm（P=0.428），而SS-OCTA和FA图像上的FAZ周长中位数分别为2.382（IQR，2.201-2.59）和2.333（IQR，2.138-2.6）mm（P=0.733）。SS-OCTA和FA图像上的无灌注区（NPA）大小无显著差异（12.389，IQR 4.96-28.3和11.125，IQR 5-28.31mm，P=0.197）。SS-OCTA和FA上的微动脉瘤（MA）总数中位数分别为35（IQR，19-46）和73（IQR，43-93）（P<0.001）。两种技术在视网膜内微血管异常（IRMA）和新生血管（NV）计数上无显著差异。上述所有参数的组内相关系数（ICC）表明具有稳定的重复性。
超广角SS-OCTA是评估DR微血管的一种可靠、无创且定量的成像技术，在DR评估中可作为FA的潜在替代方法。
