Department of Ophthalmology, Ulm University, Ulm, Germany,
Department of Ophthalmology, Ulm University, Ulm, Germany.
Ophthalmologica. 2020;243(1):21-26. doi: 10.1159/000499114. Epub 2019 May 28.
To compare typical findings of diabetic retinopathy in optical coherence tomography angiography (OCTA) and fluorescein angiography (FA).
SUBJECTS/METHODS: 42 patients were enrolled in this study. We performed FA and obtained en face 3 × 3 mm OCTA images of the macular region. The count of microaneurysms (MAs) and the size of the foveal avascular zone (FAZ) were compared. The assessability of the imaging modalities was graded in each eye.
53 eyes of 42 patients with a mean age of 61 years were included. 36/53 eyes revealed nonproliferative diabetic retinopathy, 17/53 eyes had proliferative diabetic retinopathy. The mean size of the FAZ was 0.39 mm2 in FA and 0.42 mm2 in OCTA. The mean MA count was 14 in FA and 13 in OCTA. The assessability was favorable to OCTA in 38-41/53 eyes regarding the FAZ and favorable to FA in 45-49/53 eyes regarding MAs.
We found a good agreement for the size of the FAZ and a weak agreement regarding the count of MAs in both imaging modalities. The readers favored OCTA for the assessment of the FAZ and FA for the assessment of MAs. Complementary use of FA and OCTA ensures the best diagnostic approach in patients with diabetic retinopathy.
比较光学相干断层扫描血管造影（OCTA）和荧光素血管造影（FA）中糖尿病视网膜病变的典型表现。
受试者/方法：本研究纳入了 42 名患者。我们进行了 FA，并获得了黄斑区 3×3mm 的 OCTA 图像。比较了微动脉瘤（MAs）的数量和中心凹无血管区（FAZ）的大小。对每种成像方式的可评估性进行了分级。
本研究纳入了 42 名患者的 53 只眼，平均年龄为 61 岁。36/53 只眼为非增生性糖尿病视网膜病变，17/53 只眼为增生性糖尿病视网膜病变。FA 中 FAZ 的平均大小为 0.39mm2，OCTA 中为 0.42mm2。FA 中 MA 计数的平均值为 14，OCTA 中为 13。FAZ 的评估中，OCTA 在 38-41/53 只眼中的可评估性较好，而 MA 的评估中，FA 在 45-49/53 只眼中的可评估性较好。
我们发现两种成像方式的 FAZ 大小具有良好的一致性，而 MA 数量的一致性较弱。读者倾向于 OCTA 评估 FAZ，FA 评估 MA。FA 和 OCTA 的互补使用可确保糖尿病视网膜病变患者获得最佳的诊断方法。
