Mahmoodpoor Ata, Faramarzi Elnaz, Reyhanifard Anita, Shamekh Ali, Nikanfar Saba, Azizi-Zeinalhajlou Akbar, Sanaie Sarvin
Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Liver and Gastrointestinal Diseases Research Center, Clinical Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
SN Appl Sci. 2022;4(12):326. doi: 10.1007/s42452-022-05208-4. Epub 2022 Nov 8.
Low serum selenium (Se) levels have been shown in critical illness, which is associated with poor clinical outcomes and a higher mortality rate. Se plays an important role in inflammation and oxidative stress. Since the overproduction of inflammatory cytokines and increased oxidative stress is a major component of critical illnesses, its supplementation has been demonstrated to have promising effects on critically ill patients. This study aims to review the evidence regarding the effects of Se supplementation on inflammatory and oxidative markers in critically ill patients. The literature review highlights alterations of inflammatory markers, including procalcitonin, leukocyte count, albumin, prealbumin, C-reactive protein (CRP), inflammatory cytokines, and cholesterol following Se supplementation in critically ill patients. Besides, the antioxidant properties of Se due to its presence in the structure of several selenoenzymes have been reported.
Low serum Se level have been shown in critical illness, which is associated with poor clinical outcome and higher mortality rate.Se plays an important role in inflammation and oxidative stress.Se supplementation can have promising effects by alterations of inflammatory markers and its antioxidant properties for critically ill patients.
危重病患者血清硒（Se）水平较低，这与不良临床结局及较高死亡率相关。硒在炎症和氧化应激中起重要作用。由于炎症细胞因子过度产生和氧化应激增加是危重病的主要组成部分，已证明补充硒对危重病患者有潜在疗效。本研究旨在综述补充硒对危重病患者炎症和氧化指标影响的相关证据。文献综述强调了危重病患者补充硒后炎症指标的变化，包括降钙素原、白细胞计数、白蛋白、前白蛋白、C反应蛋白（CRP）、炎症细胞因子和胆固醇。此外，还报道了由于硒存在于几种硒酶结构中而具有的抗氧化特性。
危重病患者血清硒水平较低，这与不良临床结局及较高死亡率相关。硒在炎症和氧化应激中起重要作用。补充硒可通过改变炎症指标及其抗氧化特性对危重病患者产生潜在疗效。
