Królewska-Daszczyńska Patrycja, Wendlocha Dominika, Smycz-Kubańska Marta, Stępień Sebastian, Mielczarek-Palacz Aleksandra
Department of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec Medical University of Silesia, 40-055 Katowice, Poland.
Oncol Lett. 2022 Nov 7;24(6):465. doi: 10.3892/ol.2022.13585. eCollection 2022 Dec.
Ovarian cancer is a gynecological neoplasm that can be found in women, which, due to diagnostic difficulties, is often detected at advanced stages when treatment becomes a significant problem. Moreover, in a number of cases there is a cancer recurrence and resistance to standard chemotherapy treatment. It has been suggested that cancer stem cells (CSCs) that were not eradicated during therapy may be responsible for this. For this reason, effective therapeutic methods eliminating CSCs are being studied, such as therapy targeting CSCs markers. In addition, numerous studies have also drawn attention to the usefulness of CSCs markers in predicting disease progression and assessing patient's prognosis as well as their importance in the development of treatment resistance. The present review presented research on selected CSCs markers, which may be of significant prognostic and therapeutic importance in ovarian cancer.
卵巢癌是一种可在女性身上发现的妇科肿瘤，由于诊断困难，它常在晚期才被发现，此时治疗成为一个重大问题。此外，在许多病例中会出现癌症复发以及对标准化疗治疗产生耐药性的情况。有人提出，治疗期间未被根除的癌症干细胞（CSCs）可能是造成这种情况的原因。因此，正在研究消除癌症干细胞的有效治疗方法，例如针对癌症干细胞标志物的治疗。此外，众多研究也已关注到癌症干细胞标志物在预测疾病进展、评估患者预后方面的作用，以及它们在产生治疗耐药性过程中的重要性。本综述介绍了对选定的癌症干细胞标志物的研究，这些标志物可能在卵巢癌的预后和治疗方面具有重要意义。
