干细胞与癌症干细胞：善恶并存的情形及其在干细胞治疗中的意义。
Stem Cells and Cancer Stem Cells: The Jekyll and Hyde Scenario and Their Implications in Stem Cell Therapy.
作者信息
Wan Kamarul Zaman Wan Safwani, Nurul Asma Abdullah, Nordin Fazlina
机构信息
Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Centre for Innovation in Medical Engineering (CIME), Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
出版信息
Biomedicines. 2021 Sep 17;9(9):1245. doi: 10.3390/biomedicines9091245.
"Jekyll and Hyde" refers to persons with an unpredictably dual personality, who are battling between good and evil within themselves In this regard, even cells consist of good and evil counterparts. Normal stem cells (NSCs) and cancer stem cells (CSCs) are two types of cells that share some similar characteristics but have distinct functions that play a major role in physiological and pathophysiological development. In reality, NSCs such as the adult and embryonic stem cells, are the good cells and the ultimate treatment used in cell therapy. CSCs are the corrupted cells that are a subpopulation of cancer cells within the cancer microenvironment that grow into a massive tumour or malignancy that needs to be treated. Hence, understanding the connection between NSCs and CSCs is important not just in cancer development but also in their therapeutic implication, which is the focus of this review.
“杰ekyll与海德”指的是具有不可预测的双重人格的人，他们内心在善恶之间斗争。在这方面，即使是细胞也由善恶相对的部分组成。正常干细胞（NSCs）和癌症干细胞（CSCs）是两种具有一些相似特征但功能截然不同的细胞类型，它们在生理和病理生理发展中起主要作用。实际上，诸如成体干细胞和胚胎干细胞之类的正常干细胞是好细胞，也是细胞治疗中使用的最终治疗手段。癌症干细胞是已堕落的细胞，是癌症微环境中癌细胞的一个亚群，会发展成需要治疗的巨大肿瘤或恶性肿瘤。因此，了解正常干细胞与癌症干细胞之间的联系不仅在癌症发展方面很重要，在其治疗意义方面也很重要，这正是本综述的重点。
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