Sah Mahesh Kumar, Mukherjee Sunny, Flora Bableen, Malek Naved, Rath Subha Narayan
Department of Biotechnology, Dr. B. R. Ambedkar, National Institute of Technology, Jalandhar, Punjab 144011 India.
Department of Biotechnology, Lovely Professional University, Jalandhar, Punjab India.
J Environ Health Sci Eng. 2022 Jul 31;20(2):1015-1033. doi: 10.1007/s40201-022-00815-0. eCollection 2022 Dec.
Presently on a global scale, one of the major concerns is to find effective strategies to manage the agricultural waste to protect the environment. One strategy that has been drawing attention among the researchers is the development of biocompatible materials from agricultural waste. This strategy implies successful conversion of agricultural waste products (e.g.: cellulose, eggshell etc.) into building blocks for biomaterial development. Some of these wastes contain even bioactive compounds having biomedical applications. The replacement and augmentation of human tissue with biomaterials as alternative to traditional method not only bypasses immune-rejection, donor scarcity, and maintenance; but also provides long term solution to damaged or malfunctioning organs. Biomaterials development as one of the key challenges in tissue engineering approach, resourced from natural origin imparts better biocompatibility due to closely mimicking composition with cellular microenvironment. The "Garbage In, Biomaterials Out (GIBO)" concept, not only recycles the agricultural wastes, but also adds to biomaterial raw products for further product development in tissue regeneration. This paper reviews the conversion of garbage agricultural by-products to the biocompatible materials for various biomedical applications.
The agro-waste biomass processed, purified, modified, and further utilized for the fabrication of biomaterials-based support system for tissue engineering applications to grow living body parts in vitro or in vivo.
目前在全球范围内，主要关注点之一是找到管理农业废弃物以保护环境的有效策略。在研究人员中引起关注的一种策略是利用农业废弃物开发生物相容性材料。该策略意味着成功地将农业废弃物产品（如纤维素、蛋壳等）转化为生物材料开发的基础材料。其中一些废弃物甚至含有具有生物医学应用的生物活性化合物。用生物材料替代和补充人体组织作为传统方法的替代方案，不仅绕过了免疫排斥、供体稀缺和维护问题；还为受损或功能失调的器官提供了长期解决方案。生物材料开发是组织工程方法中的关键挑战之一，源自天然的生物材料由于与细胞微环境的组成密切相似，具有更好的生物相容性。“垃圾进，生物材料出（GIBO）”概念不仅回收了农业废弃物，还为组织再生中的进一步产品开发增加了生物材料原料产品。本文综述了将农业垃圾副产品转化为用于各种生物医学应用的生物相容性材料的过程。
农业废弃物生物质经过加工、纯化、改性，进一步用于制造基于生物材料的支持系统，用于组织工程应用，以在体外或体内培育活体组织。
