Ogura Shinji, Seo Kohei, Ichihara Mitsuyoshi, Ichizuka Kiyotake, Nagatsuka Masaaki
Department of Obstetrics and Gynecology, Showa University Northern Yokohama Hospital, Kanagawa, Japan.
J Clin Med Res. 2022 Oct;14(10):409-415. doi: 10.14740/jocmr4816. Epub 2022 Oct 28.
The aim of the study is to analyze the impact of the geriatric nutritional risk index (a patient nutritional assessment item) on the prognoses of epithelial ovarian cancer patients.
In this retrospective study conducted at a single hospital, we retrospectively analyzed 75 epithelial ovarian cancer patients who underwent surgical treatment at our hospital from 2010 to 2015. The geriatric nutritional risk index cut-off value was calculated using the receiver operating characteristic curve. Patients were divided into two groups on the basis of the calculated value. Kaplan-Meier curves were prepared for each group, and the difference in survival rates was calculated using the log-rank test. Cox proportional hazards regression analysis was used to compare other factors that affect prognosis.
The geriatric nutritional risk index was calculated to be 97.3. The survival rate was 61.9% for the group of patients with an index value > 97.3, and 39.4% for patients with an index value < 97.3 at 48 months (P < 0.001). A univariate analysis was performed with the following variables: age > 60 years, albumin level < 3.5 g/dL, body mass index < 22, presence of ascites, cancer antigen 125 level > 35 U/mL, type of tumor tissue, residual lesion, and geriatric nutritional risk index < 97.3. Albumin level, residual lesion, and geriatric nutritional risk index showed significant differences. A multivariate analysis was also performed, and only the geriatric nutritional risk index showed a significant difference (P = 0.0481).
The geriatric nutritional risk index may have a strong influence on the prognoses of epithelial ovarian cancer patients. We recommend utilizing these findings in daily clinical practice and incorporating them into treatment strategies for epithelial ovarian cancer.
本研究旨在分析老年营养风险指数（一项患者营养评估指标）对上皮性卵巢癌患者预后的影响。
在一家医院开展的这项回顾性研究中，我们回顾性分析了2010年至2015年在我院接受手术治疗的75例上皮性卵巢癌患者。使用受试者工作特征曲线计算老年营养风险指数的临界值。根据计算值将患者分为两组。为每组绘制Kaplan-Meier曲线，并使用对数秩检验计算生存率差异。采用Cox比例风险回归分析比较其他影响预后的因素。
计算得出老年营养风险指数为97.3。指数值>97.3的患者组在48个月时的生存率为61.9%，指数值<97.3的患者组为39.4%（P<0.001）。对以下变量进行单因素分析：年龄>60岁、白蛋白水平<3.5g/dL、体重指数<22、存在腹水、癌抗原125水平>35U/mL、肿瘤组织类型、残留病灶以及老年营养风险指数<97.3。白蛋白水平、残留病灶和老年营养风险指数显示出显著差异。还进行了多因素分析，只有老年营养风险指数显示出显著差异（P = 0.0481）。
老年营养风险指数可能对上上皮性卵巢癌患者的预后有很大影响。我们建议在日常临床实践中利用这些发现，并将其纳入上皮性卵巢癌的治疗策略中。
