身高降低与心血管疾病的关联：来自韩国一个大型队列的数据。

Association of height loss and cardiovascular disease: Data from a large Korean cohort.

作者信息

Moon Jeonggeun, Oh Pyung Chun, Lee Kyounghoon, Jang Ho-Jun, Kim Tae-Hoon, Park Sang-Don, Kwon Sung Woo, Kong Min Gyu, Suh Jon, Kang Woong Chol

机构信息

Division of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.

Department of Cardiology, Sejong General Hospital, Bucheon, South Korea.

出版信息

Front Cardiovasc Med. 2022 Nov 4;9:1026597. doi: 10.3389/fcvm.2022.1026597. eCollection 2022.

DOI:10.3389/fcvm.2022.1026597

PMID:36407463

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9671925/

Abstract

BACKGROUND

Height declines with age, and its degree differs among individuals. Despite epidemiologic evidence for the inverse relationship between adult height and cardiovascular disease (CVD) incidence, the clinical significance of height loss in CVD remains to be elucidated. Therefore, this study investigated the association between height loss and CVD incidence.

METHODS

In total, 127,573 Korean participants were enrolled; their heights were monitored from 2002 to 2011. The annual height loss (cm/year) was the difference between the first and last height measurements within the observation period divided by the number of years. The participants were classified as Group 1 (height loss: <0.3 cm/year; = 102,554), Group 2 (height loss: 0.3- < 0.6 cm/year; = 17,324), or Group 3 (height loss: ≥0.6 cm/year; = 7,695).

RESULTS

The cumulative major adverse cardiac and cerebral event (MACCE: cardiac death, non-fatal myocardial infarction, and unplanned hospitalization for heart failure or stroke) incidence rate was 3.6% for Group 1, 4.5% for Group 2, and 5.2% for Group 3. Group 2 (hazard ratio [HR] = 1.27, 95% confidence interval [CI] = 1.17-1.37) and Group 3 (HR = 1.46, 95% CI = 1.32-1.62) had a significantly higher incidence of MACCE than Group 1. In the model adjusted for age, sex, comorbidities, income level, body mass index, smoking, and drinking status, the MACCE risk was higher in Group 2 (HR = 1.11, 95% CI = 1.07-1.20) and Group 3 (HR = 1.25, 95% CI = 1.13-1.39) than in Group 1.

CONCLUSION

The degree of height loss was independently associated with CVD occurrences in the Korean population.

摘要

背景

身高会随着年龄增长而下降，且个体之间的下降程度有所不同。尽管有流行病学证据表明成人身高与心血管疾病（CVD）发病率呈负相关，但身高下降在心血管疾病中的临床意义仍有待阐明。因此，本研究调查了身高下降与心血管疾病发病率之间的关联。

方法

总共纳入了127,573名韩国参与者；在2002年至2011年期间对他们的身高进行监测。年身高下降幅度（厘米/年）为观察期内首次和末次身高测量值之差除以观察年数。参与者被分为第1组（身高下降幅度：<0.3厘米/年；n = 102,554）、第2组（身高下降幅度：0.3 - <0.6厘米/年；n = 17,324）或第3组（身高下降幅度：≥0.6厘米/年；n = 7,695）。

结果

第1组累积主要不良心脑血管事件（MACCE：心源性死亡、非致死性心肌梗死以及因心力衰竭或中风而计划外住院）发病率为3.6%，第2组为4.5%，第3组为5.2%。第2组（风险比[HR] = 1.27，95%置信区间[CI] = 1.17 - 1.37）和第3组（HR = 1.46，95% CI = 1.32 - 1.62）的MACCE发病率显著高于第1组。在对年龄、性别、合并症、收入水平、体重指数、吸烟和饮酒状况进行校正的模型中，第2组（HR = 1.11，95% CI = 1.07 - 1.20）和第3组（HR = 1.25，95% CI = 1.13 - 1.39）的MACCE风险高于第1组。