来自皮肤的胶原蛋白肽对环磷酰胺诱导的小鼠氧化损伤的影响。

Effects of collagen peptides from skin on oxidative damage induced by cyclophosphamide in mice.

作者信息

Han Mengyao, Zhang Zhongshan, Li Xinyue, Tong Haibin, Xu Zhiguo, Ding Zikang, Yang Anquan, Xie Min, Wang Xiaomei

机构信息

Zhejiang Provincial Key Laboratory of Aquatic Resources Conservation and Development, Huzhou University, Huzhou, China.

College of Life and Environmental Sciences, Wenzhou University, Wenzhou, China.

出版信息

Front Nutr. 2022 Nov 3;9:1037212. doi: 10.3389/fnut.2022.1037212. eCollection 2022.

To investigate the protective effect of collagen peptide from skin (CPMs) on oxidative damage induced by cyclophosphamide in mice. Balb/c female mice were divided into blank, model (cyclophosphamide, CTX), positive control (levamisole hydrochloride), and collagen peptide low-, medium-, and high-dose groups. The results showed that CPMs increase the body mass and immune-related organ indexes, such as liver and kidneys of immunosuppressed mice. The activities of ALT, AST, UA, BUN, and MDA in the liver and kidney tissues decreased significantly, while those of SOD and GSH-Px increased significantly. CPMs can relieve the pathological damage to immune organs. CPMs significantly increase the activities of IL-2, IgG, and TNF-α in serum and SOD activity, while the MDA content was decreased compared to the model group. CPMs can exert a protective effect on cyclophosphamide-induced oxidative damage and have application prospects in the field of health food.

为研究皮肤来源的胶原蛋白肽（CPMs）对环磷酰胺诱导的小鼠氧化损伤的保护作用。将Balb/c雌性小鼠分为空白组、模型组（环磷酰胺，CTX）、阳性对照组（盐酸左旋咪唑）以及胶原蛋白肽低、中、高剂量组。结果表明，CPMs可增加免疫抑制小鼠的体重以及肝脏和肾脏等免疫相关器官指数。肝、肾组织中谷丙转氨酶（ALT）、谷草转氨酶（AST）、尿酸（UA）、尿素氮（BUN）和丙二醛（MDA）的活性显著降低，而超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性显著增加。CPMs可减轻对免疫器官的病理损伤。与模型组相比，CPMs显著提高血清中白细胞介素-2（IL-2）、免疫球蛋白G（IgG）和肿瘤坏死因子-α（TNF-α）的活性以及SOD活性，同时降低MDA含量。CPMs对环磷酰胺诱导的氧化损伤具有保护作用，在保健食品领域具有应用前景。