School of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450002, PR China; Henan Key Laboratory of Cold Chain Food Quality and Safety Control, Zhengzhou 450002, PR China; Collaborative Innovation Center of Food Production and Safety, Henan Province, PR China.
College of Geography and Land Engineering, Yuxi Normal University, Yuxi, Yunnan 653100, PR China.
Int J Biol Macromol. 2020 Jun 15;153:248-255. doi: 10.1016/j.ijbiomac.2020.02.315. Epub 2020 Feb 27.
Inflammation is the first response of the body's immune system to injury, infection and stress. Chronic inflammation has close relationship with many diseases, such as arthritis, atherosclerosis and cancer. The traditional therapy strategy of inflammation mainly involves steroid and non-steroid anti-inflammatory drugs, both of which have increasingly prominent side-effects which cannot be ignored. Polysaccharides extracted from natural sources have attracted extensive attention in recent years owing to their safety, accessibility and potent anti-inflammatory activities, but systematic introduction about their function in anti-inflammation is still absent. So here, we summarized the recent reports of natural polysaccharides with anti-inflammatory effects, mainly focusing on the various pharmacological mechanisms and targets involved. The structure-anti-inflammatory activity relationships are also discussed in detail. It is supposed that our review will benefit the understanding of the value of polysaccharides in anti-inflammation and further provide guidance for the development and application of novel anti-inflammatory agents in clinic.
炎症是机体免疫系统对损伤、感染和应激的第一反应。慢性炎症与许多疾病密切相关，如关节炎、动脉粥样硬化和癌症。炎症的传统治疗策略主要涉及甾体和非甾体抗炎药物，两者都具有日益突出的不可忽视的副作用。近年来，从天然来源提取的多糖由于其安全性、易得性和有效的抗炎活性而引起了广泛关注，但系统介绍其抗炎功能仍然缺乏。因此，在这里，我们总结了具有抗炎作用的天然多糖的最新报道，主要集中在涉及的各种药理机制和靶点上。还详细讨论了结构-抗炎活性关系。我们认为，我们的综述将有助于理解多糖在抗炎中的价值，并为开发和应用新型抗炎药物提供指导。
