Zhang Changteng, Gao Rui, Zhou Ruihao, Chen Hai, Liu Changliang, Zhu Tao, Chen Chan
Department of Anesthesiology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu, China.
Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Front Mol Neurosci. 2022 Nov 3;15:1037929. doi: 10.3389/fnmol.2022.1037929. eCollection 2022.
Chronic pain (CP) is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage lasting longer than 3 months. CP is the main reason why people seek medical care and exerts an enormous economic burden. Genome-wide expression analysis has revealed that diverse essential genetic elements are altered in CP patients. Although many possible mechanisms of CP have been revealed, we are still unable to meet all the analgesic needs of patients. In recent years, non-coding RNAs (ncRNAs) have been shown to play essential roles in peripheral neuropathy and axon regeneration, which is associated with CP occurrence and development. Multiple key ncRNAs have been identified in animal models of CP, such as microRNA-30c-5p, ciRS-7, and lncRNA MRAK009713. This review highlights different kinds of ncRNAs in the regulation of CP, which provides a more comprehensive understanding of the pathogenesis of the disease. It mainly focuses on the contributions of miRNAs, circRNAs, and lncRNAs to CP, specifically peripheral neuropathic pain (NP), diabetic NP, central NP associated with spinal cord injury, complex regional pain syndrome, inflammatory pain, and cancer-induced pain. In addition, we summarize some potential ncRNAs as novel biomarkers for CP and its complications. With an in-depth understanding of the mechanism of CP, ncRNAs may provide novel insight into CP and could become new therapeutic targets in the future.
慢性疼痛（CP）是一种不愉快的感觉和情感体验，与实际或潜在的组织损伤相关，或类似于与之相关的体验，持续时间超过3个月。慢性疼痛是人们寻求医疗护理的主要原因，并带来了巨大的经济负担。全基因组表达分析表明，慢性疼痛患者体内多种重要的基因元件发生了改变。尽管已经揭示了许多慢性疼痛可能的发病机制，但我们仍无法满足患者所有的镇痛需求。近年来，非编码RNA（ncRNAs）已被证明在周围神经病变和轴突再生中发挥重要作用，而这与慢性疼痛的发生和发展相关。在慢性疼痛动物模型中已鉴定出多种关键的非编码RNA，如微小RNA-30c-5p、环状RNA-7（ciRS-7）和长链非编码RNA MRAK009713。本综述重点介绍了不同类型的非编码RNA在慢性疼痛调控中的作用，这有助于更全面地了解该疾病的发病机制。它主要关注微小RNA（miRNAs）、环状RNA（circRNAs）和长链非编码RNA（lncRNAs）对慢性疼痛的影响，特别是对周围神经病理性疼痛（NP）、糖尿病性周围神经病变、与脊髓损伤相关的中枢性神经病理性疼痛、复杂性区域疼痛综合征、炎性疼痛和癌症诱导性疼痛的影响。此外，我们总结了一些潜在的非编码RNA作为慢性疼痛及其并发症的新型生物标志物。随着对慢性疼痛机制的深入了解，非编码RNA可能为慢性疼痛提供新的见解，并可能在未来成为新的治疗靶点。
