Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Orthopedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Jishuitan Orthopaedic College of Tsinghua University, Beijing, China.
Cell Prolif. 2019 Jan;52(1):e12528. doi: 10.1111/cpr.12528. Epub 2018 Oct 25.
Neuropathic pain, a type of chronic and potentially disabling pain resulting from primary injury/dysfunction of the somatosensory nervous system and spinal cord injury, is one of the most intense types of chronic pain, which incurs a significant economic and public health burden. However, our understanding of its cellular and molecular pathogenesis is still far from complete. Long non-coding RNAs (lncRNAs) are important regulators of gene expression and have recently been characterized as key modulators of neuronal functions. Emerging evidence suggested that lncRNAs are deregulated and play pivotal roles in the development of neuropathic pain. This review summarizes the current knowledge about the roles of deregulated lncRNAs (eg, KCNA2-AS, uc.48+, NONRATT021972, MRAK009713, XIST, CCAT1) in the development of neuropathic pain. These studies suggested that specific regulation of lncRNAs or their downstream targets might provide novel therapeutic avenues for this refractory disease.
神经病理性疼痛是一种由躯体感觉神经系统原发性损伤/功能障碍和脊髓损伤引起的慢性、潜在致残性疼痛，是最剧烈的慢性疼痛之一，给社会带来了巨大的经济和公共卫生负担。然而，我们对其细胞和分子发病机制的理解还远远不够。长链非编码 RNA（lncRNA）是基因表达的重要调控因子，最近被认为是神经元功能的关键调节剂。新出现的证据表明，lncRNA 失调并在神经病理性疼痛的发展中发挥关键作用。这篇综述总结了目前关于失调的 lncRNA（如 KCNA2-AS、uc.48+、NONRATT021972、MRAK009713、XIST、CCAT1）在神经病理性疼痛发展中的作用的知识。这些研究表明，lncRNA 或其下游靶标的特定调节可能为这种难治性疾病提供新的治疗途径。
