Gong Yan, Luo Yi, Chen Zhilai, Sui Ying, Zheng Yansong
Health Management Institute, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
The 6th Health Department, Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.
Open Med (Wars). 2022 Nov 3;17(1):1742-1749. doi: 10.1515/med-2022-0564. eCollection 2022.
This research aimed to analyze lifestyle-related factors which influence () infection and outcomes in Chinese adults. A single-center, retrospective study was performed from January 2012 to December 2020. Self-administered questionnaires were used to collect relevant lifestyle information, and the C-urea breath test was used to diagnose active infection. A total of 18,211 subjects were enrolled in the study, of which 5,511 were females (30.26%). Subjects were studied longitudinally for up to five follow-up visits. At baseline, gastric test was negative in 10,670 subjects (58.59%) and positive in 7,541 subjects (41.41%). Males exhibited a significantly higher infection rate than females (38.56% vs 2.65%, respectively; = 26.45, < 0.001). Throughout the course of follow-up, positive rates in the subjects decreased ( = 666.04, < 0.001). Among the subjects with baseline negative results, 3-6% changed from negative to positive during follow-up. In contrast, among those with baseline positive results, >70% remained positive, and 21-26% changed from positive to negative. However, only 22-27% of -infected subjects received pharmacotherapy. The results indicate the prevalence of infection is high in the Chinese population. That additional effort is required to prevent and control infection.
本研究旨在分析影响中国成年人幽门螺杆菌感染及预后的生活方式相关因素。2012年1月至2020年12月进行了一项单中心回顾性研究。采用自行填写的问卷收集相关生活方式信息，并采用碳-尿素呼气试验诊断幽门螺杆菌现症感染。共有18211名受试者纳入研究，其中女性5511名（30.26%）。对受试者进行长达5次随访的纵向研究。基线时，10670名受试者（58.59%）的幽门螺杆菌检测为阴性，7541名受试者（41.41%）为阳性。男性的幽门螺杆菌感染率显著高于女性（分别为38.56%和2.65%；χ² = 26.45，P < 0.001）。在整个随访过程中，受试者的幽门螺杆菌阳性率下降（χ² = 666.04，P < 0.001）。在基线结果为阴性的受试者中，3%-6%在随访期间从阴性转为阳性。相反，在基线结果为阳性的受试者中，>70%仍为阳性，21%-26%从阳性转为阴性。然而，只有22%-27%的幽门螺杆菌感染受试者接受了药物治疗。结果表明，中国人群中幽门螺杆菌感染率较高。需要付出更多努力来预防和控制幽门螺杆菌感染。
