Liu Ying, Li Dongyu, Liu Yuping, Shuai Ping
Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Front Med (Lausanne). 2021 Dec 24;8:764472. doi: 10.3389/fmed.2021.764472. eCollection 2021.
Both nonalcoholic fatty liver disease (NAFLD) and () infection have high prevalence worldwide, and the relationship between both remains controversial. We try to investigate whether infection is associated with NAFLD and increased liver fat deposition and stiffness in this cross-sectional study. The physical examination data of 5,665 subjects were obtained from February 2018 to June 2019 in this study. Clinical and biochemical data were collected. NAFLD was diagnosed using abdominal color Doppler ultrasonography. Liver steatosis and stiffness were understood by two parameters of transient elastography (TE): fat attenuation parameter (FAP) and liver stiffness measurement (LSM). infection was determined using the C urea breath tests. The total prevalence of NAFLD and infection was 30.2 and 37.0%, respectively. In men, the prevalence of NAFLD and the levels of FAP and LSM in -positive group were significantly higher than -negative group (all < 0.01), but no significant difference was found in women. In men, the infection rate of in NAFLD group and LSM ≥ 7.4 kPa group was significantly higher than control group. Multivariate logistic regression analysis revealed that infection was not independently associated with NAFLD and FAP ≥ 240 dB/m. However, infection was associated with LSM ≥ 7.4 kPa in men. Our study suggests that infection is not significantly associated with NAFLD and elevated liver steatosis, whereas it may be the risk factor of elevated liver stiffness in men.
非酒精性脂肪性肝病（NAFLD）和（）感染在全球范围内都有很高的患病率，两者之间的关系仍存在争议。在这项横断面研究中，我们试图调查（）感染是否与NAFLD以及肝脏脂肪沉积和硬度增加有关。本研究于2018年2月至2019年6月获取了5665名受试者的体格检查数据。收集了临床和生化数据。使用腹部彩色多普勒超声诊断NAFLD。通过瞬时弹性成像（TE）的两个参数来了解肝脏脂肪变性和硬度：脂肪衰减参数（FAP）和肝脏硬度测量值（LSM）。使用C尿素呼气试验确定（）感染情况。NAFLD和（）感染的总患病率分别为30.2%和37.0%。在男性中，（）阳性组的NAFLD患病率以及FAP和LSM水平显著高于（）阴性组（均P<0.01），但在女性中未发现显著差异。在男性中，NAFLD组和LSM≥7.4 kPa组的（）感染率显著高于对照组。多因素逻辑回归分析显示，（）感染与NAFLD和FAP≥240 dB/m无独立相关性。然而，（）感染与男性LSM≥7.4 kPa有关。我们的研究表明，（）感染与NAFLD和肝脏脂肪变性升高无显著相关性，而它可能是男性肝脏硬度升高的危险因素。
