Zeng Fan, Lan Yunping, Wang Ning, Huang Xiaobo, Zhou Qiao, Wang Yi
Department of Critical Care Medicine, Sichuan Academy of Medical Science, Chengdu, China.
Department of Rheumatology and Immunology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Front Pharmacol. 2022 Nov 3;13:1043283. doi: 10.3389/fphar.2022.1043283. eCollection 2022.
Bladder cancer (BC) is the most frequent type of urinary system cancer. The prognosis of BC is poor due to high metastasis rates and multidrug resistance. Hence, development of novel therapies targeting BC cell death is urgently needed. As a novel cell death type with strong antitumor potential, ferroptosis has been investigated by many groups for its potential in BC treatment. As an iron-dependent cell death process, ferroptosis is characterized by excessive oxidative phospholipids. The molecular mechanisms of ferroptosis include iron overload and the system Xc-GSH-GPX4 signaling pathway. A recent study revealed that ferroptosis is involved in the metastasis, treatment, and prognosis of BC. Herein, in this review, we comprehensively summarize the mechanism of ferroptosis, address newly identified targets involved in ferroptosis, and discuss the potential of new clinical therapies targeting ferroptosis in BC.
膀胱癌（BC）是泌尿系统癌症中最常见的类型。由于高转移率和多药耐药性，BC的预后较差。因此，迫切需要开发针对BC细胞死亡的新型疗法。作为一种具有强大抗肿瘤潜力的新型细胞死亡类型，铁死亡已被许多研究团队研究其在BC治疗中的潜力。作为一种铁依赖性细胞死亡过程，铁死亡的特征是氧化磷脂过量。铁死亡的分子机制包括铁过载和系统Xc-GSH-GPX4信号通路。最近的一项研究表明，铁死亡与BC的转移、治疗和预后有关。在此综述中，我们全面总结了铁死亡的机制，阐述了新发现的参与铁死亡的靶点，并讨论了针对BC中铁死亡的新临床疗法的潜力。
