He Xia, Wang Ning, Zhang Yu, Huang Xiaobo, Wang Yi
Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Department of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Front Pharmacol. 2022 Nov 2;13:1051952. doi: 10.3389/fphar.2022.1051952. eCollection 2022.
Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Saponins and their metabolites These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment.
胰腺癌是消化道最恶性的肿瘤之一，预后较差，5年生存率低于10%。尽管手术切除和以吉西他滨（一线治疗）为主的化疗已应用于胰腺癌患者，但由于耐药性，胰腺癌的总体生存率仍然很低。因此，迫切需要开发替代治疗策略。在这篇综述中，我们总结了主要的草药及其代谢产物，包括姜黄素、雷公藤甲素、皂苷及其代谢产物。这些具有抗氧化、抗血管生成和抗转移活性的化合物可以抑制胰腺癌的进展和转移。期望提供潜在天然产物的全面信息，我们的综述为胰腺癌治疗提供了有价值的信息和策略。
