• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Complete Structural Predictions of the Proteome of African Swine Fever Virus Strain Georgia 2007.非洲猪瘟病毒格鲁吉亚2007株蛋白质组的完整结构预测
Microbiol Resour Announc. 2022 Dec 15;11(12):e0088122. doi: 10.1128/mra.00881-22. Epub 2022 Nov 21.
2
Development of a Highly Effective African Swine Fever Virus Vaccine by Deletion of the I177L Gene Results in Sterile Immunity against the Current Epidemic Eurasia Strain.通过缺失I177L基因开发高效非洲猪瘟病毒疫苗可产生针对当前流行的欧亚毒株的无菌免疫。
J Virol. 2020 Mar 17;94(7). doi: 10.1128/JVI.02017-19.
3
African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus.携带MGF360和MGF505基因缺失的非洲猪瘟病毒格鲁吉亚分离株在猪中减毒，并能抵御强毒亲本病毒的攻击。
J Virol. 2015 Jun;89(11):6048-56. doi: 10.1128/JVI.00554-15. Epub 2015 Mar 25.
4
Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge.从非洲猪瘟病毒格鲁吉亚2007分离株中同时删除9GL和UK基因可提高安全性并抵御同源攻击。
J Virol. 2016 Dec 16;91(1). doi: 10.1128/JVI.01760-16. Print 2017 Jan 1.
5
Deletion of the A137R Gene from the Pandemic Strain of African Swine Fever Virus Attenuates the Strain and Offers Protection against the Virulent Pandemic Virus.从非洲猪瘟病毒流行株中删除 A137R 基因可减弱该毒株的毒力，并提供针对强毒力流行病毒的保护。
J Virol. 2021 Oct 13;95(21):e0113921. doi: 10.1128/JVI.01139-21. Epub 2021 Aug 18.
6
African Swine Fever Virus and Host Response: Transcriptome Profiling of the Georgia 2007/1 Strain and Porcine Macrophages.非洲猪瘟病毒与宿主反应：格鲁吉亚 2007/1 株与猪巨噬细胞的转录组谱分析。
J Virol. 2022 Mar 9;96(5):e0193921. doi: 10.1128/jvi.01939-21. Epub 2022 Jan 12.
7
Deletion of E184L, a Putative DIVA Target from the Pandemic Strain of African Swine Fever Virus, Produces a Reduction in Virulence and Protection against Virulent Challenge.缺失非洲猪瘟病毒流行株中的假定 DIVA 靶点 E184L 可降低病毒毒力并提供针对强毒攻击的保护。
J Virol. 2022 Jan 12;96(1):e0141921. doi: 10.1128/JVI.01419-21. Epub 2021 Oct 20.
8
African swine fever virus vaccine candidate ASFV-G-ΔI177L efficiently protects European and native pig breeds against circulating Vietnamese field strain.非洲猪瘟病毒候选疫苗ASFV-G-ΔI177L能有效保护欧洲和本地猪种抵御越南流行的田间毒株。
Transbound Emerg Dis. 2022 Jul;69(4):e497-e504. doi: 10.1111/tbed.14329. Epub 2021 Oct 15.
9
Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic Pigs.从格鲁吉亚分离株中删除非洲猪瘟病毒组蛋白样蛋白 A104R 可极大降低病毒在家猪中的毒力。
Viruses. 2022 May 22;14(5):1112. doi: 10.3390/v14051112.
10
Deletion of the thymidine kinase gene induces complete attenuation of the Georgia isolate of African swine fever virus.缺失胸苷激酶基因可诱导非洲猪瘟病毒佐治亚分离株完全减毒。
Virus Res. 2016 Feb 2;213:165-171. doi: 10.1016/j.virusres.2015.12.002. Epub 2015 Dec 4.

引用本文的文献

1
Deletion of the African Swine Fever Virus Gen in the Georgia2010 Isolate Genome Does Not Affect Virus Replication or Virulence in Domestic Pigs.删除格鲁吉亚2010分离株基因组中的非洲猪瘟病毒基因对家猪体内病毒复制或毒力无影响。
Viruses. 2025 Apr 23;17(5):603. doi: 10.3390/v17050603.
2
Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank.在RCSB蛋白质数据库中探索实验确定的PDB结构和计算结构模型的更新资源。
Nucleic Acids Res. 2025 Jan 6;53(D1):D564-D574. doi: 10.1093/nar/gkae1091.
3
Identification of linear B cell epitopes on the E146L protein of African swine fever virus with monoclonal antibodies.用单克隆抗体鉴定非洲猪瘟病毒 E146L 蛋白上的线性 B 细胞表位。
Virol J. 2024 Nov 12;21(1):286. doi: 10.1186/s12985-024-02570-0.
4
A Retrospective Analysis Reveals That the 2021 Outbreaks of African Swine Fever Virus in Ghana Were Caused by Two Distinct Genotypes.一项回顾性分析显示，加纳 2021 年暴发的非洲猪瘟病毒由两种截然不同的基因型引起。
Viruses. 2024 Aug 7;16(8):1265. doi: 10.3390/v16081265.
5
Viroporin-like activity of the hairpin transmembrane domain of African swine fever virus B169L protein.非洲猪瘟病毒 B169L 蛋白发夹跨膜结构域的病毒孔道样活性。
J Virol. 2024 Aug 20;98(8):e0023124. doi: 10.1128/jvi.00231-24. Epub 2024 Jul 9.
6
Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010.在IPKM细胞系中生产的重组疫苗株ASFV-G-Δ9GL/ΔUK基因稳定，对用强毒非洲猪瘟病毒田间分离株格鲁吉亚2010攻击的猪具有诱导保护作用。
Pathogens. 2024 Apr 13;13(4):319. doi: 10.3390/pathogens13040319.
7
Deletion of the EP402R Gene from the Genome of African Swine Fever Vaccine Strain ASFV-G-∆I177L Provides the Potential Capability of Differentiating between Infected and Vaccinated Animals.删除非洲猪瘟疫苗株 ASFV-G-∆I177L 基因组中的 EP402R 基因提供了区分感染动物和接种疫苗动物的潜在能力。
Viruses. 2024 Feb 28;16(3):376. doi: 10.3390/v16030376.
8
Evaluation of the Deletion of the African Swine Fever Virus Gene from the Genome of the Georgia Isolate.评估格鲁吉亚分离株基因组中非洲猪瘟病毒基因的缺失。
Viruses. 2023 Oct 23;15(10):2134. doi: 10.3390/v15102134.
9
African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge.非洲猪瘟疫苗候选株 ASFV-G-ΔI177L 在猪源巨噬细胞衍生细胞系 IPKM 中制备保持遗传稳定性并可有效抵抗同源强毒攻击。
Viruses. 2023 Oct 8;15(10):2064. doi: 10.3390/v15102064.
10
Comparative genomic and transcriptomic analyses of African swine fever virus strains.非洲猪瘟病毒株的比较基因组学和转录组学分析
Comput Struct Biotechnol J. 2023 Aug 29;21:4322-4335. doi: 10.1016/j.csbj.2023.08.028. eCollection 2023.

本文引用的文献

1
African swine fever in the Dominican Republic.多米尼加共和国的非洲猪瘟
Transbound Emerg Dis. 2021 Nov;68(6):3018-3019. doi: 10.1111/tbed.14341. Epub 2021 Oct 10.
2
Highly accurate protein structure prediction with AlphaFold.利用 AlphaFold 进行高精度蛋白质结构预测。
Nature. 2021 Aug;596(7873):583-589. doi: 10.1038/s41586-021-03819-2. Epub 2021 Jul 15.
3
The structural basis of African swine fever virus core shell protein p15 binding to DNA.非洲猪瘟病毒核心壳蛋白 p15 与 DNA 结合的结构基础。
FASEB J. 2021 Mar;35(3):e21350. doi: 10.1096/fj.202002145R.
4
Structure and Biochemical Characteristic of the Methyltransferase (MTase) Domain of RNA Capping Enzyme from African Swine Fever Virus.非洲猪瘟病毒RNA加帽酶甲基转移酶（MTase）结构域的结构与生化特性
J Virol. 2021 Mar 1;95(5). doi: 10.1128/JVI.02029-20. Epub 2020 Dec 2.
5
Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development.宿主和非洲猪瘟病毒 dUTP 酶的结构比较为抑制剂开发提供了新的线索。
J Biol Chem. 2021 Jan-Jun;296:100015. doi: 10.1074/jbc.RA120.014005. Epub 2020 Nov 23.
6
Structure basis of non-structural protein pA151R from African Swine Fever Virus.非洲猪瘟病毒非结构蛋白 pA151R 的结构基础。
Biochem Biophys Res Commun. 2020 Oct 29;532(1):108-113. doi: 10.1016/j.bbrc.2020.08.011. Epub 2020 Aug 20.
7
Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly.非洲猪瘟病毒结构蛋白p35的晶体结构揭示了其在核心壳组装中的作用。
Protein Cell. 2020 Aug;11(8):600-605. doi: 10.1007/s13238-020-00730-w.
8
The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives.非洲猪瘟病毒 pA104R 与 DNA 结合的结构基础及其与芪类衍生物的抑制作用。
Proc Natl Acad Sci U S A. 2020 May 19;117(20):11000-11009. doi: 10.1073/pnas.1922523117. Epub 2020 May 1.
9
A unique DNA-binding mode of African swine fever virus AP endonuclease.非洲猪瘟病毒脱嘌呤嘧啶内切酶独特的DNA结合模式。
Cell Discov. 2020 Mar 17;6:13. doi: 10.1038/s41421-020-0146-2. eCollection 2020.
10
Crystal Structure of African Swine Fever Virus pS273R Protease and Implications for Inhibitor Design.非洲猪瘟病毒 pS273R 蛋白酶的晶体结构及其抑制剂设计的意义。
J Virol. 2020 May 4;94(10). doi: 10.1128/JVI.02125-19.

非洲猪瘟病毒格鲁吉亚2007株蛋白质组的完整结构预测

Complete Structural Predictions of the Proteome of African Swine Fever Virus Strain Georgia 2007.

作者信息

Spinard Edward, Azzinaro Paul, Rai Ayushi, Espinoza Nallely, Ramirez-Medina Elizabeth, Valladares Alyssa, Borca Manuel V, Gladue Douglas P

机构信息

Plum Island Animal Disease Center, Agricultural Research Service, USDA, Greenport, New York, USA.

Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, Tennessee, USA.

出版信息

Microbiol Resour Announc. 2022 Dec 15;11(12):e0088122. doi: 10.1128/mra.00881-22. Epub 2022 Nov 21.

DOI:10.1128/mra.00881-22
PMID:36409113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9753626/
Abstract

Here, we announce the predicted structures of the 193 proteins encoded by African swine fever virus (ASFV) strain Georgia 2007 (ASFV-G). Previously, only the structures of 16 ASFV proteins were elucidated.

摘要

在此，我们公布了非洲猪瘟病毒（ASFV）格鲁吉亚2007株（ASFV-G）编码的193种蛋白质的预测结构。此前，仅阐明了16种ASFV蛋白质的结构。