来自[植物名称]茎皮的四环三萜类化合物及其对MCF-7乳腺癌细胞的细胞毒性活性。 （注：原文中“from the stem bark of ”后面缺少具体植物名称）
Tirucallane-type triterpenoid from the stem bark of and its cytotoxic activity against MCF-7 breast cancer cells.
作者信息
Parulian Samuel San, Naini Al Arofatus, Hilmayanti Erina, Farabi Kindi, Harneti Desi, Mayanti Tri, Maharani Rani, Herlina Tati, Supratman Unang, Anwar Risyandi, Fajriah Sofa, Azmi Mohamad Nurul, Prescott Thomas, Shiono Yoshihito
机构信息
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka 560-0043, Japan.
出版信息
J Asian Nat Prod Res. 2023 Jul-Aug;25(8):803-809. doi: 10.1080/10286020.2022.2143353. Epub 2022 Nov 21.
Chisocarpene A () is a new tirucallane-type triterpenoid together with odoratone () and 24-methylenecycloartanol (), isolated from the stem bark of . The chemical structures of compounds were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay. Compound showed the most potent activity (IC 26.56 ± 1.01 µM) and was two-fold more active than the positive control.
奇索卡烯A（）是一种新的羽扇豆烷型三萜类化合物，与奥多他酮（）和24-亚甲基环阿尔廷醇（）一起，从的茎皮中分离得到。通过对其光谱数据（红外光谱、质谱、一维和二维核磁共振）的详细分析，阐明了化合物的化学结构。使用基于刃天青的试验，对分离得到的化合物进行了针对MCF-7乳腺癌细胞系的细胞毒性活性评估。化合物表现出最强的活性（IC 26.56±1.01µM），其活性是阳性对照的两倍。
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