Nguyen Thi-Ngoc-Nuong, Vo Thi-Nga, Nguyen Kim-Phi-Phung, Nguyen Tri-Hieu, Nguyen Thi-Anh-Tuyet
Department of Organic Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2025 Jul;39(14):4033-4039. doi: 10.1080/14786419.2024.2330539. Epub 2024 Mar 23.
A new cucurbitacin, 3-(-D-glucopyranosyloxy)-5,6:16,23-diepoxycucurbit-24-en-11-one or hygrocucurbin A , along with two known compounds, including 3-(-D-glucopyranosyloxy)-16,23-epoxycucurbita-5,24-dien-11-one and (+)-lyoniresinol , were isolated from the bark of . Their chemical structures were elucidated by spectroscopic NMR, HR-IDA- TOF-MS analysis, and by comparison with the spectral data of corresponding compounds in the literature. Two cucurbitacins and were evaluated for their -glucosidase inhibitory activity and cytotoxic against KB, MCF-7, Hep G2, and A549 cancer cell lines. For the -glucosidase inhibitory activity, compound showed an equivalent effect (IC 197.4 ± 4.1 µM) compared to the acarbose, a positive control (IC 208.5 ± 4.7 µM). And for the cytotoxicity, was inactive while was slightly sensitive against KB cells (IC 233.3 ± 2.5 µM).
从[植物名称]树皮中分离出一种新的葫芦素，即3-(-D-吡喃葡萄糖氧基)-5,6:16,23-二环氧葫芦-24-烯-11-酮或湿生葫芦素A，以及两种已知化合物，包括3-(-D-吡喃葡萄糖氧基)-16,23-环氧葫芦-5,24-二烯-11-酮和(+)-裂环马钱子素。通过光谱核磁共振、高分辨电感耦合等离子体质谱分析以及与文献中相应化合物的光谱数据进行比较，阐明了它们的化学结构。对两种葫芦素进行了α-葡萄糖苷酶抑制活性和对KB、MCF-7、Hep G2和A549癌细胞系的细胞毒性评估。对于α-葡萄糖苷酶抑制活性，化合物[具体化合物]与阳性对照阿卡波糖（IC50 208.5±4.7μM）相比显示出等效效果（IC50 197.4±4.1μM）。对于细胞毒性，[具体化合物]无活性，而[具体化合物]对KB细胞略有敏感性（IC50 233.3±2.5μM）。
