A new cucurbitane - type triterpenoid from the bark of Kurz.

A new cucurbitacin, 3-(-D-glucopyranosyloxy)-5,6:16,23-diepoxycucurbit-24-en-11-one or hygrocucurbin A , along with two known compounds, including 3-(-D-glucopyranosyloxy)-16,23-epoxycucurbita-5,24-dien-11-one and (+)-lyoniresinol , were isolated from the bark of . Their chemical structures were elucidated by spectroscopic NMR, HR-IDA- TOF-MS analysis, and by comparison with the spectral data of corresponding compounds in the literature. Two cucurbitacins and were evaluated for their -glucosidase inhibitory activity and cytotoxic against KB, MCF-7, Hep G2, and A549 cancer cell lines. For the -glucosidase inhibitory activity, compound showed an equivalent effect (IC 197.4 ± 4.1 µM) compared to the acarbose, a positive control (IC 208.5 ± 4.7 µM). And for the cytotoxicity, was inactive while was slightly sensitive against KB cells (IC 233.3 ± 2.5 µM).