Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts, USA.
Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
J Infect Dis. 2023 May 12;227(10):1127-1131. doi: 10.1093/infdis/jiac462.
In the Northeast and upper Midwest of the United States, Babesia microti and Borrelia burgdorferi use Ixodes scapularis ticks as vector and Peromyscus leucopus mice as major reservoir host. We previously established, in a 5-year field trial, that a reservoir-targeted outer surface protein A vaccine reduces the prevalence of B. burgdorferi-infected ticks. We accessed ticks and mouse blood samples collected during the trial, extracted total DNA, and amplified the B. microti 18S rRNA gene. Vaccine deployment reduced the prevalence of ticks coinfected with B. microti and that of mice infected with B. microti. Breaking the enzootic cycle of B. burgdorferi may reduce the incidence of babesiosis.
在美国东北部和中西部上地区，微小巴贝斯虫和伯氏疏螺旋体通过肩突硬蜱作为媒介，白足鼠作为主要储存宿主。我们之前在一项为期 5 年的野外试验中建立了一个针对储存宿主的外表面蛋白 A 疫苗，该疫苗可以降低伯氏疏螺旋体感染的蜱的流行率。我们利用试验期间采集的蜱和鼠血样，提取总 DNA，并扩增微小巴贝斯虫 18S rRNA 基因。疫苗的使用降低了同时感染微小巴贝斯虫的蜱和感染微小巴贝斯虫的鼠的流行率。打破伯氏疏螺旋体的地方性循环可能会降低巴贝斯虫病的发病率。
