Menis Mikhail, Whitaker Barbee I, Wernecke Michael, Jiao Yixin, Eder Anne, Kumar Sanjai, Xu Wenjie, Liao Jiemin, Wei Yuqin, MaCurdy Thomas E, Kelman Jeffrey A, Anderson Steven A, Forshee Richard A
Food and Drug Administration, Silver Spring, Maryland, USA.
Acumen LLC, Burlingame, California, USA.
Open Forum Infect Dis. 2020 Dec 15;8(2):ofaa608. doi: 10.1093/ofid/ofaa608. eCollection 2021 Feb.
Human babesiosis is a mild-to-severe parasitic infection that poses health concerns especially in older and other at-risk populations. The study objective was to assess babesiosis occurrence among US Medicare beneficiaries, ages 65 and older, during 2006-2017.
Our retrospective claims-based study used Medicare databases. Babesiosis cases were identified using recorded diagnosis codes. The study estimated rates (per 100 000 beneficiary-years) overall, by year, diagnosis month, demographics, and state and county of residence.
Nationwide, 19 469 beneficiaries had babesiosis recorded, at a rate of 6 per 100 000 person-years, ranging from 4 in 2006 to 9 in 2017 ( < .05). The highest babesiosis rates by state were in the following: Massachusetts (62), Rhode Island (61), Connecticut (51), New York (30), and New Jersey (19). The highest rates by county were in the following: Nantucket, Massachusetts (1089); Dukes, Massachusetts (236); Barnstable, Massachusetts (213); and Dutchess, New York (205). Increasing rates, from 2006 through 2017 ( < .05), were identified in multiple states, including states previously considered nonendemic. New Hampshire, Maine, Vermont, Pennsylvania, and Delaware saw rates increase by several times.
Our 12-year study shows substantially increasing babesiosis diagnosis trends, with highest rates in well established endemic states. It also suggests expansion of babesiosis infections in other states and highlights the utility of real-world evidence.
人巴贝斯虫病是一种从轻度到重度的寄生虫感染，对健康构成威胁，尤其是在老年人和其他高危人群中。本研究的目的是评估2006 - 2017年期间美国65岁及以上医疗保险受益人中巴贝斯虫病的发病情况。
我们基于医疗保险数据库进行回顾性索赔研究。通过记录的诊断代码识别巴贝斯虫病病例。该研究按总体、年份、诊断月份、人口统计学特征以及居住州和县估计发病率（每100 000受益人次年）。
在全国范围内，有19469名受益人记录有巴贝斯虫病，发病率为每100 000人年6例，范围从2006年的4例到2017年的9例（P < 0.05）。按州划分，巴贝斯虫病发病率最高的是：马萨诸塞州（62例）、罗德岛州（61例）、康涅狄格州（51例）、纽约州（30例）和新泽西州（19例）。按县划分，发病率最高的是：马萨诸塞州的楠塔基特（1089例）；马萨诸塞州的杜克斯（236例）；马萨诸塞州的巴恩斯特布尔（213例）；以及纽约州（205例）达奇斯。在多个州发现从2006年到2017年发病率呈上升趋势（P < 0.05），包括以前认为非流行的州。新罕布什尔州、缅因州、佛蒙特州、宾夕法尼亚州和特拉华州的发病率增加了几倍。
我们的12年研究表明，巴贝斯虫病诊断趋势大幅上升，在已确定的流行州发病率最高。这也表明其他州巴贝斯虫病感染范围在扩大，并突出了真实世界证据的效用。
