非酒精性脂肪性肝病患者发生早发冠状动脉粥样硬化的风险。
Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease.
机构信息
Trakya University, Faculty of Medicine, Department of Cardiology - Edirne, Turkey.
Trakya University, Faculty of Medicine, Department of Radiology - Edirne, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2022 Nov 21;68(10):1428-1433. doi: 10.1590/1806-9282.20220514. eCollection 2022.
OBJECTIVE
In the current literature, there are few studies investigating the relationship between premature coronary atherosclerosis and nonalcoholic fatty liver disease. We aimed to evaluate the relationship between nonalcoholic fatty liver disease and premature coronary atherosclerosis.
METHODS
In this cross-sectional study, female patients aged <55 years and male patients aged <50 years were enrolled. Both male and female patients underwent coronary angiography and abdomen ultrasonography between 2014 and 2019. A stepwise binary logistic regression analysis was carried out to evaluate the independent variables related to premature coronary atherosclerosis and nonalcoholic fatty liver disease. A p-value<0.05 was considered statistically significant.
RESULTS
nonalcoholic fatty liver disease was present in 44% of patients (n=377). Notably, 62% of the patients were female and the mean age was 44.5 (39-49) years. In a multivariate analysis, nonalcoholic fatty liver disease was shown to be an independent risk factor of premature coronary atherosclerosis (OR 1.438; 95%CI, 1.050-1.969; p=0.024).
CONCLUSIONS
The presence of nonalcoholic fatty liver disease is an important independent risk factor for the development of premature coronary atherosclerosis.
目的
在当前的文献中，很少有研究调查非酒精性脂肪肝与早发冠状动脉粥样硬化之间的关系。我们旨在评估非酒精性脂肪肝与早发冠状动脉粥样硬化之间的关系。
方法
本横断面研究纳入了 2014 年至 2019 年间年龄<55 岁的女性患者和年龄<50 岁的男性患者。所有男性和女性患者均接受了冠状动脉造影和腹部超声检查。采用逐步二元逻辑回归分析评估与早发冠状动脉粥样硬化和非酒精性脂肪肝相关的独立变量。p 值<0.05 被认为具有统计学意义。
结果
非酒精性脂肪肝在 44%的患者（n=377）中存在。值得注意的是，62%的患者为女性，平均年龄为 44.5（39-49）岁。在多变量分析中，非酒精性脂肪肝是早发冠状动脉粥样硬化的独立危险因素（OR 1.438；95%CI，1.050-1.969；p=0.024）。
结论
非酒精性脂肪肝的存在是非酒精性脂肪肝患者早发冠状动脉粥样硬化的一个重要独立危险因素。
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