Li Xiao-Lin, Sui Jian-Qing, Lu Lin-Lin, Zhang Nan-Nan, Xu Xin, Dong Quan-Yong, Xin Yong-Ning, Xuan Shi-Ying
Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, 266011, China.
Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, 266011, China.
Lipids Health Dis. 2016 Mar 10;15:53. doi: 10.1186/s12944-016-0221-8.
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which represents a wide spectrum of hepatic damage. Several studies have reported that NAFLD is a strong independent risk factor for coronary artery disease (CAD). And patients with NAFLD are at higher risk and suggested undergoperiodic cardiovascular risk assessment. Cardiovascular disease (CVD) is responsible for the main cause of death in patients with NAFLD, and is mostly influenced by genetic factors. Both NAFLD and CAD are heterogeneous disease. Common pathways involved in the pathogenesis of NAFLD and CAD includes insulin resistance (IR), atherogenic dyslipidemia, subclinical inflammation, oxidative stress, etc. Genomic characteristics of these two diseases have been widely studied, further research about the association of these two diseases draws attention. The gene polymorphisms of adiponectin-encoding gene (ADIPOQ), leptin receptor (LEPR), apolipoprotein C3 (APOC3), peroxisome proliferator-activated receptors (PPAR), sterol regulatory elementbinding proteins (SREBP), transmembrane 6 superfamily member 2 (TM6SF2), microsomal triglyceride transfer protein (MTTP), tumor necrosis factors-alpha (TNF-α) and manganese superoxide dismutase (MnSOD) have been reported to be related to NAFLD and CAD. In this review, we aimed to provide an overview of recent insights into the genetic basis of NAFLD and CAD.
非酒精性脂肪性肝病（NAFLD）是一种常见的慢性肝病，代表了广泛的肝损伤。多项研究报告称，NAFLD是冠状动脉疾病（CAD）的一个强大独立危险因素。NAFLD患者风险更高，建议进行定期心血管风险评估。心血管疾病（CVD）是NAFLD患者的主要死因，且主要受遗传因素影响。NAFLD和CAD都是异质性疾病。NAFLD和CAD发病机制中涉及的共同途径包括胰岛素抵抗（IR）、致动脉粥样硬化血脂异常、亚临床炎症、氧化应激等。这两种疾病的基因组特征已得到广泛研究，关于这两种疾病关联的进一步研究引起了关注。据报道，脂联素编码基因（ADIPOQ）、瘦素受体（LEPR）、载脂蛋白C3（APOC3）、过氧化物酶体增殖物激活受体（PPAR）、固醇调节元件结合蛋白（SREBP）、跨膜6超家族成员2（TM6SF2）、微粒体甘油三酯转移蛋白（MTTP）、肿瘤坏死因子-α（TNF-α）和锰超氧化物歧化酶（MnSOD）的基因多态性与NAFLD和CAD有关。在本综述中，我们旨在概述对NAFLD和CAD遗传基础的最新见解。
