Uchida Kenji, Iida Kenichi, Fujioka Ikumi, Hachimura Satoshi, Kaminuma Osamu
R&D Center, Yotsuba Milk Products Co., Ltd., Sapporo 061-1264, Japan.
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Pathogens. 2022 Nov 14;11(11):1347. doi: 10.3390/pathogens11111347.
Accumulating evidence suggests that subsp. YRC3780 isolated from kefir has the potential to alleviate allergic responses. Herein, we investigated the effect of YRC3780 on a murine model of Japanese cedar pollinosis (JCP). BALB/c mice immunized with cedar pollen extract (CPE) exhibited an increase in serum immunoglobulin E and developed nasal inflammatory responses including sneezing, nasal hyperresponsiveness, and nasal eosinophil accumulation upon intranasal allergen challenge. These responses were suppressed by the oral administration of YRC3780, although the effects on CPE-induced sneezing response and eosinophil infiltration were not statistically significant. Total fecal microbiota diversity was not affected by allergen immunization and challenge or by YRC3780 administration. However, the abundances of , , , and were larger and that of was smaller in YRC3780-treated mice compared with those in CPE-challenged and YRC3780-untreated mice. Our findings suggest the usefulness of YRC3780 for alleviating JCP.
越来越多的证据表明，从开菲尔中分离出的亚种YRC3780具有减轻过敏反应的潜力。在此，我们研究了YRC3780对日本雪松花粉症（JCP）小鼠模型的影响。用雪松花粉提取物（CPE）免疫的BALB/c小鼠血清免疫球蛋白E增加，并在鼻内过敏原激发后出现包括打喷嚏、鼻高反应性和鼻嗜酸性粒细胞积聚在内的鼻炎症反应。口服YRC3780可抑制这些反应，尽管对CPE诱导的打喷嚏反应和嗜酸性粒细胞浸润的影响无统计学意义。总粪便微生物群多样性不受过敏原免疫和激发或YRC3780给药的影响。然而，与CPE激发且未用YRC3780处理的小鼠相比，用YRC3780处理的小鼠中，[此处原文缺失具体菌名]的丰度更高，而[此处原文缺失具体菌名]的丰度更低。我们的研究结果表明YRC3780对减轻JCP有用。
