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反复性小肠梗阻,一种罕见的未确诊类肉瘤病的表现。

Recurrent small bowel obstruction as a rare presentation of undiagnosed sarcoidosis.

机构信息

Medicine, University of Florida, Gainesville, Florida, USA

Medicine, University of Florida, Gainesville, Florida, USA.

出版信息

BMJ Case Rep. 2022 Nov 24;15(11):e252486. doi: 10.1136/bcr-2022-252486.

Abstract

Sarcoidosis is an immune-mediated inflammatory disorder with unknown aetiology that is marked by non-caseating granulomas in affected organs. Pulmonary sarcoidosis is the most common manifestation, but gastrointestinal involvement, particularly in the small bowel, is exceedingly rare. While symptom-driven treatment guidelines that are steroid based are well established for pulmonary and few extrapulmonary manifestations (ie, cardiac, neurologic, renal), gastrointestinal sarcoidosis treatment is largely extrapolation with optimal management under investigation. Additionally, few works document small bowel obstruction related to small bowel sarcoidosis. We present a case of short-interval recurrent small bowel obstruction in a man in his sixties that revealed newly diagnosed sarcoidosis with suspected small bowel involvement who never underwent steroid therapy. The patient exhibited gastrointestinal symptoms, despite asymptomatic pulmonary disease and a course of prednisone may have reduced his risk of recurrence. We also review suggested gastrointestinal sarcoidosis treatment and surveillance guidelines with focus on the small bowel.

摘要

结节病是一种病因不明的免疫介导性炎症性疾病,其特征是受累器官中有非干酪样肉芽肿。肺结节病是最常见的表现,但胃肠道受累,特别是小肠,极为罕见。虽然基于类固醇的症状驱动治疗指南已广泛应用于肺部和少数肺外表现(如心脏、神经、肾脏),但胃肠道结节病的治疗主要是通过推断,最佳管理方法仍在研究中。此外,很少有文献记录与小肠结节病相关的小肠梗阻。我们报告了一例六十多岁男性的短间隔复发性小肠梗阻,该患者新诊断为结节病,伴有疑似小肠受累,但从未接受过类固醇治疗。尽管该患者肺部疾病无症状,但仍表现出胃肠道症状,接受泼尼松治疗可能降低了他的复发风险。我们还回顾了建议的胃肠道结节病治疗和监测指南,重点关注小肠。

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