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评价非标准抗体对中国人群抗磷脂综合征患者的诊断价值。

Evaluation of the Diagnostic Value of Non-criteria Antibodies for Antiphospholipid Syndrome Patients in a Chinese Cohort.

机构信息

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China.

出版信息

Front Immunol. 2021 Sep 10;12:741369. doi: 10.3389/fimmu.2021.741369. eCollection 2021.

DOI:10.3389/fimmu.2021.741369
PMID:34567005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8461188/
Abstract

OBJECTIVE

Although specific anti-phospholipid antibodies (aPLs) have been used in the diagnosis of the antiphospholipid syndrome (APS) for years, new biomarkers are required to increase its diagnostic and risk-predictive power. This study aimed to explore the value of several non-criteria aPLs in a Chinese cohort.

METHODS

A total of 312 subjects, namely, 100 patients diagnosed with primary APS, 51 with APS secondary to SLE, 71 with SLE, and 90 healthy controls, were recruited. Serum anticardiolipin (aCL) IgG/IgM/IgA, anti-β2-glycoprotein I (aβ2GPI) IgG/IgM/IgA, anti-phosphatidylserine/prothrombin antibodies (aPS/PT) IgG/IgM, and anti-annexin A5 antibodies (aAnxV) IgG/IgM were tested using ELISA kits.

RESULTS

Of the total number of patients, 30.46% and 6.62% with APS were positive for aCL or aβ2GPI IgA, respectively, while 39.07% and 24.50% were positive for aAnxV or aPS/PT for at least one antibody (IgG or IgM). The addition test of aCL IgA and aAnxV IgM assists in identifying seronegative APS patients, and IgG aPS/PT was linked to stroke.

CONCLUSION

Detection of aCL IgA, aβ2GPI IgA, aAnxV IgG/M, and aPS/PT IgG/M as a biomarker provides additive value in APS diagnosis and would help in risk prediction for APS patients in medical practice.

摘要

目的

尽管特定的抗磷脂抗体 (aPL) 已用于抗磷脂综合征 (APS) 的诊断多年，但仍需要新的生物标志物来提高其诊断和风险预测能力。本研究旨在探索几种非标准 aPL 在中国人队列中的价值。

方法

共纳入 312 例受试者，即 100 例原发性 APS 患者、51 例 SLE 继发 APS 患者、71 例 SLE 患者和 90 例健康对照者。采用 ELISA 试剂盒检测血清抗心磷脂 (aCL) IgG/IgM/IgA、抗β2-糖蛋白 I (aβ2GPI) IgG/IgM/IgA、抗磷脂酰丝氨酸/凝血酶原抗体 (aPS/PT) IgG/IgM 和抗膜联蛋白 A5 抗体 (aAnxV) IgG/IgM。

结果

在所有患者中，30.46%和 6.62%的 APS 患者 aCL 或 aβ2GPI IgA 阳性，而 39.07%和 24.50%的 APS 患者至少有一种抗体 (IgG 或 IgM) 的 aAnxV 或 aPS/PT 阳性。aCL IgA 和 aAnxV IgM 的联合检测有助于识别血清阴性 APS 患者，而 IgG aPS/PT 与中风相关。

结论

检测 aCL IgA、aβ2GPI IgA、aAnxV IgG/M 和 aPS/PT IgG/M 作为生物标志物可增加 APS 诊断的附加价值，并有助于在临床实践中对 APS 患者进行风险预测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f917/8461188/9721f0ebb3ea/fimmu-12-741369-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f917/8461188/74c698fe06c5/fimmu-12-741369-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f917/8461188/3521167a7284/fimmu-12-741369-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f917/8461188/9721f0ebb3ea/fimmu-12-741369-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f917/8461188/74c698fe06c5/fimmu-12-741369-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f917/8461188/3521167a7284/fimmu-12-741369-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f917/8461188/9721f0ebb3ea/fimmu-12-741369-g003.jpg

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